Publisher's Synopsis
This study examines a variety of organisms and systems to illustrate the common features of chromosome behavior, mechanisms for their distribution and errors in transmittal. The book uses genetic, biochemical, antibody and direct karyotyping methodologies to study thoroughly the occurrence of whole chromosomal aneuploidy. This comprehensive work examines all aspects of the segregational apparatus, the processes of segregation, the chromosome components and interactions, the errors and correctional systems that might give rise to malsegregation, as well as agents, both physical and chemical, that may alter the segregation. It emphasizes chromosomal components, specifically focusing on the centromere and the kinetochore. The text will be of interest to cell biologists, biochemists and geneticists.
