Structural Bioinformatics

Structural Bioinformatics was the first major effort to show the application of the principles and basic knowledge of the larger field of bioinformatics to questions focusing on macromolecular structure, such as the prediction of protein structure and how proteins carry out cellular functions, and how the application of bioinformatics to these life science issues can improve healthcare by accelerating drug discovery and development. Designed primarily as a reference, the first edition nevertheless saw widespread use as a textbook in graduate and undergraduate university courses dealing with the theories and associated algorithms, resources, and tools used in the analysis, prediction, and theoretical underpinnings of DNA, RNA, and proteins. This new edition contains not only thorough updates of the advances in structural bioinformatics since publication of the first edition, but also features eleven new chapters dealing with frontier areas of high scientific impact, including: sampling and search techniques; use of mass spectrometry; genome functional annotation; and much more. Offering detailed coverage for practitioners while remaining accessible to the novice, Structural Bioinformatics, Second Edition is a valuable resource and an excellent textbook for a range of readers in the bioinformatics and advanced biology fields. Praise for the previous edition: "This book is a gold mine of fundamental and practical information in an area not previously well represented in book form." -Biochemistry and Molecular Education "...destined to become a classic reference work for workers at all levels in structural bioinformatics...recommended with great enthusiasm for educators, researchers, and graduate students." -BAMBED "...a useful and timely summary of a rapidly expanding field." -Nature Structural Biology "...a terrific job in this timely creation of a compilation of articles that appropriately addresses this issue." -Briefings in Bioinformatics

ISBN 0470181052   Volumes 1 ISBN13 9780470181058 (What's this?)   Weight (grammes) 1864 Publisher John Wiley and Sons Ltd   Published in Chicester Imprint Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)   Series ISSN 44 Format Hardback   Series title Methods of Biochemical Analysis Publication date 03 Apr 2009   Previous ISBN 9780471201991 Library of Congress QH324.2   Height (mm) 260 DEWEY 572   Width (mm) 186 DEWEY edition DC22   Spine width (mm) 45 Pages 1036   Academic level Professional / Scholarly

Sect. I		Data Collection, Analysis, and Visualization		1
1		Defining Bioinformatics and Structural Bioinformatics by Russ B. Altman and Jonathan M. Dugan		3
2		Fundamentals of Protein Structure by Eric D. Scheeff and J. Lynn Fink		15
3		Fundamentals of DNA and RNA Structure by Stephen Neidle and Bohdan Schneider and Helen M. Berman		41
4		Computational Aspects of High-Throughput Crystallographic Macromolecular Structure Determination by Paul D. Adams and Ralf W. Grosse-Kunstleve and Axel T. Brunger		77
5		Macromolecular Structure Determination by NMR Spectroscopy by John L. Markley and Arash Bahrami and Hamid R. Eghbalnia and Francis C. Peterson and Robert C. Tyler and Eldon L. Ulrich and William M. Westler and Brian F. Volkman		93
6		Electron Microscopy in the Context of Structural Systems Biology by Niels Volkmann and Dorit Hanein		143
7		Study of Protein Three-Dimensional Structure and Dynamics Using Peptide Amide Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS) and Chemical Cross-Linking with Mass Spectrometry to Constrain Molecular Modeling by Sheng Li and Dmitri Mouradov and Gordon King and Tong Liu and Ian Ross and Bostjan Kobe and Virgil L. Woods, Jr. and Thomas Huber		171
8		Search and Sampling in Structural Bioinformatics by Ilan Samish		207
9		Molecular Visualization by Steven Bottomley and Erik Helmerhorst		237
Sect. II		Data Representation and Databases		269
10		The PDB Format, mmCIF Formats, and Other Data Formats by John D. Westbrook and Paula M. D. Fitzgerald		271
11		The Worldwide Protein Data Bank by Helen M. Berman and Kim Henrick and Haruki Nakamura and John L. Markley		293
12		The Nucleic Acid Database by Bohdan Schneider and Joanna de la Cruz and Zukang Feng and Li Chen and Shuchismita Dutta and Irina Persikova and John D. Westbrook and Huanwang Yang and Jasmine Young and Christine Zardecki and Helen M. Berman		305
13		Other Structure-Based Databases by J. Lynn Fink and Helge Weissig and Philip E. Bourne		321
Sect. III		Data Integrity and Comparative Features		339
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"Offering a detailed coverage for practitioners but remaining accessible to the novice, Structural Bioinformatics, Second Edition is a valuable and excellent textbook for readers in the bioinformatics and advanced biology fields, and on the best way to become a classic reference for all interested parties (educators, researchers and graduate students.)" (Advances in Food Sciences, 2011)

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