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The different LC-MS techniques available today were developed to suit specific analytical needs and the application range covered by each one is wide, but still limited. GC amenable compounds can be all analysed with a single GC-MS system whereas HPLC applications call for specific LC-MS instrumental arrangements. ESI, APCI, APPI, and EI are ionization techniques that can be combined with different analysers, in single or tandem configuration, to create the ultimate system for a certain application. Once approaching LC-MS for a specific need, the fast technical evolution and the variegated commercial offer can induce confusion in the potential user. The role of this book is to enlighten the state-of-the-art of LC-MS evolution through a series of contributions written by the people that brought major, recent innovations in the field. Each chapter will take into consideration the novelties, the advantages and the possible applications covered by a particular technical solution. The book will also include new analytical methods that can provide benefits using the most recent innovations in LC-MS plus a certain number of key applications. It contains contributions from major innovators in the field. It covers the latest developments in the field of LC-MS and gives a clear outline on the advantages of various techniques and their applications.
| ISBN | 0444527737 | | Volumes | 1 | | ISBN13 | 9780444527738
(What's this?) | | Weight (grammes) | 640 | | Publisher | Elsevier Science & Technology | | Published in | Oxford | | Imprint | Elsevier Science Ltd | | Series ISSN | 72 | | Format | Hardback | | Series title | Journal of Chromatography Library | | Publication date | 05 Dec 2006 | | Height (mm) | 240 | | Library of Congress | QD79.C454 | | Width (mm) | 165 | | DEWEY | 543 | | Spine width (mm) | 17 | | DEWEY edition | DC22 | | Academic level | Professional / Scholarly | | Pages | 274 | |
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| 1 | | Basic aspects of electrospray ionization by Laura Molin and Pietro Traldi | | 1 | | 2 | | Atmospheric pressure chemical ionization (APCI) : new avenues for an old friend by Andrea Raffaelli | | 11 | | 3 | | Electron ionization in LC-MS : a technical overview of the direct EI interface by Achille Cappiello and Pierangela Palma | | 27 | | 4 | | Electron ionization LC-MS with supersonic molecular beams by Ori Granot and Aviv Amirav | | 45 | | 5 | | A case for congruent multiple ionization modes in atmospheric pressure ionization mass spectrometry by Michael P. Balogh | | 65 | | 6 | | Atmospheric pressure laser ionization (APLI) by Oliver J. Schmitz and Thorsten Benter | | 89 | | 7 | | LC-ICP-MS - a primary tool for elemental speciation studies? by Katarzyna Wrobel and Kazimierz Wrobel and Joseph A. Caruso | | 115 | | 8 | | HPCL-chip/MS : a new approach to nano-LC/MS by Tom A. van de Goor | | 165 | | 9 | | Matrix effect, signal suppression and enhancement in LC-ESI-MS by Loris Tonidandel and Roberta Sergalia | | 193 | | 10 | | Differential mobility spectrometry (FAIMS) : a powerful tool for rapid gas phase ion separation and detection by Raanan A. Miller and Erkinjon G. Nazarov and Daren Levin | | 211 |
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