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ISBN: 9780470972441 - Antibacterial Agents
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Antibacterial Agents

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Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

Rosaleen J. Anderson, Paul W. Groundwater, Adam Todd, Alan Worsley

ISBN: 9780470972441
Format: Hardback
Publisher:John Wiley and Sons Ltd
Also available as an eBook


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Antibacterial agents act against bacterial infection either bykilling the bacterium or by arresting its growth. They do this bytargeting bacterial DNA and its associated processes, attackingbacterial metabolic processes including protein synthesis, orinterfering with bacterial cell wall synthesis and function.

 

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Antibacterial agents act against bacterial infection either bykilling the bacterium or by arresting its growth. They do this bytargeting bacterial DNA and its associated processes, attackingbacterial metabolic processes including protein synthesis, orinterfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this importantclass of chemotherapeutic drugs. Compounds are organised accordingto their target, which helps the reader understand the mechanism ofaction of these drugs and how resistance can arise. The book usesan integrated lab-to-clinic approach which coversdrug discovery, source or synthesis, mode of action, mechanisms ofresistance, clinical aspects (including links to currentguidelines, significant drug interactions, cautions andcontraindications), prodrugs and future improvements. Agents covered include: * agents targeting DNA - quinolone, rifamycin, and nitroimidazoleantibacterial agents * agents targeting metabolic processes - sulfonamideantibacterial agents and trimethoprim * agents targeting protein synthesis - aminoglycoside, macrolideand tetracycline antibiotics, chloramphenicol, andoxazolidinones * agents targeting cell wall synthesis - -Lactam andglycopeptide antibiotics, cycloserine, isonaizid, anddaptomycin

Antibacterial Agents will find a place on the bookshelvesof students of pharmacy, pharmacology, pharmaceutical sciences,drug design/discovery, and medicinal chemistry, and as a benchreference for pharmacists and pharmaceutical researchers inacademia and industry.

 
 

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