Biomechanics and Cells

Although the effects of exercise and mechanical forces on musculoskeletal and cardiovascular systems have been well documented, the actual mechanisms by which mechanical forces act at the cellular level are not well understood. At present, studies of the interaction of mechanical forces with cells encompass many different cell types in various tissues. This volume draws together these apparently disparate observations and makes comparisons between the nature of cellular responses in different tissues. Studies of cells derived from skeletal muscle, bone and cardiovascular tissue are considered to provide a comprehensive synthesis and review of recent work. The volume will be of interest to all those working in musculoskeletal and cardiovascular biology, as well as those taking courses in exercise and sport science, biomechanics and orthopaedics.

ISBN 0521454549   Pages 287 ISBN13 9780521454544 (What's this?)   Volumes 1 Publisher Cambridge University Press   Weight (grammes) 594 Imprint Cambridge University Press   Published in Cambridge Format Hardback   Series ISSN 0054 Publication date 28 Apr 1994   Series title Society for Experimental Biology Seminar Series Non-book description xii, 275 p. :   Height (mm) 228 Library of Congress QH513 .B555 1994   Width (mm) 152 DEWEY 611.018   Spine width (mm) 19 DEWEY edition DC20   Academic level Professional / Scholarly

		List of contributors
		Signal transduction pathways in vascular cells exposed to cyclic strain by B. E. Sumpio and W. Du and C. R. Cohen and L. Evans and C. Isales and O. R. Rosales and I. Mills		3
		Effects of pressure overload on vascular smooth muscle cells by F. Lyall and M. R. Deehan		23
		Effect of increased flow on release of vasoactive substances from vascular endothelial cells by P. Bodin and A. Loesch and P. Milner and G. Burnstock		37
		Modulation of endothelium-derived relaxing factor activity by flow by T. M. Griffith and I. R. Hutcheson		61
		Stretch, overload and gene expression in muscle by G. Goldspink and G.-F. Gerlach and T. Jaenicke and P. Butterworth		81
		Stretch sensitivity in stretch receptor neurones by S. E. Blackshaw		96
		Mechanical interactions with plant cells: a selective overview by J. S. Heslop-Harrison		107
		Mechanical tensing of cells and chromosome arrangement by A. S. G. Curtis		121
		Alterations in gene expression induced by low-frequency, low-intensity electromagnetic fields by B. Reipert		131
		Cellular modelling of mechanical interactions with the skeleton by A. J. El Haj and G. P. Thomas		147
		Mechanical and hormonal influences in vivo cause regional differences in bone remodelling by T. M. Skerry and B. F. Fermor		164
		Mechanically sensitive cells in bone by L. E. Lanyon		178
		Mechanical stress and bone development by E. H. Burger and J. Klein-Nulend and J. P. Veldhuijzen		187
		Application of homogenous, defined strains to cell cultures by D. B. Jones and G. Leivseth and Y. Sawada and J. van der Sloten and D. Bingmann		197
		Role of arachidonate in load transduction in bone cells by I. Binderman		220
		Effects of mechanical stretch on actin polymerisation in fibroblasts of the periodontium by N. Pender and C. A. G. McCulloch		228
		Modulation of cartilage extracellular matrix turnover by pulsed electromagnetic fields (PEMF) by J. A. Bee and H.-X. Liu and N. Clarke and J. Abbott		244
		Index		271

"The strengths of this book include the diversity of cell types and physiological responses covered, the significant detail on the putative biological mechanisms by which mechanical stimuli may be transduced by cells, and most of all the variety and detail of the experimental models, preparations, and devices that are described...an interesting collection of articles on mechanical signal transduction by cells in a variety of experimental settings." A.D. McCulloch, Applied Mechanics Review

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