Cell Volume Regulation

This volume presents a unique compilation of reviews on cell volume regulation in health and disease, with contributions from leading experts in the field. The topics covered include mechanisms and signaling of cell volume regulation and the effect of cell volume on cell function, with special emphasis on ion channels and transporters, kinases and gene expression. Several chapters elaborate on how cell volume regulatory mechanisms participate in the regulation of epithelial transport, urinary concentration, metabolism, migration, cell proliferation and apoptosis. Last but not least, this publication is an excellent guide to the role of cell volume in the pathophysiology of hypercatabolism, diabetes mellitus, brain edema, hemoglobinopathies, tumor growth and metastasis, to name just a few. Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.

ISBN 3805567375   Pages 264 ISBN13 9783805567374 (What's this?)   Volumes 001 Publisher S Karger AG   Weight (grammes) 920 Imprint S Karger AG   Published in Basel Format Hardback   Series editor Berlyne, G.M., Ronco, C. Publication date 14 Sep 1998   Series ISSN 0302-514 Library of Congress QP90.6.C43   Series title Contributions to Nephrology S. DEWEY 616.61   Height (mm) 230 DEWEY edition DC21   Academic level Undergraduate, Postgraduate, Professional / Scholarly

		Preface
		Introduction to Cell Volume Regulatory Mechanisms by S. Waldegger and J. Matskevitch and G. L. Busch		1
		Cell Volume-Regulated Cation Channels by F. Wehner		8
		Cell Volume-Sensitive Chloride Channels by Y. Okada		21
		Mechanisms of Osmolyte Release by R. K. H. Kinne		34
		Sensors and Signal Transduction in the Activation of Cell Volume Regulatory Ion Transport Systems by E. K. Hoffmann and St. F. Pedersen		50
		Activation of Protein Kinases upon Volume Changes: Role in Cellular Homeostasis by L. D. Shrode and E. Krump and S. Grinstein		79
		Intracellular Signaling in Response to Osmotic Stress by D. Kultz and M. B. Burg		94
		Approaches to Identifying Cell Volume-Regulated Genes by A. Chevaile and B. Santos and J. Randall		110
		The Cytoskeleton in Cell Volume Regulation by A. Moustakas and P. A. Theodoropoulos and A. Gravanis		121
		Cell Volume Regulatory Ion Transport in Cell Migration by M. Ritter		135
		Cell Volume in Cell Proliferation and Apoptotic Cell Death by F. Lang and A. Lepple-Wienhues and I. Szabo		158
		Cellular Osmoregulation in Kidney Medulla by F.-X. Beck and W. G. Guder and M. Schmolke		169
		Osmoregulation of Liver Cell Function: Signalling, Osmolytes and Cell Heterogeneity by D. Haussinger		185
		Volume Regulation and 'Cross-Talk' in Sodium-Absorbing Epithelial Cells by St. G. Schultz and W. P. Dubinsky and J.-Y. Lapointe		205
		Pathophysiology of Abnormal Cell Volume in Human Red Cells by J. C. Ellory and J. S. Gibson and G. W. Stewart		220
		Swelling-Activated Release of Excitatory Amino Acids in the Brain: Relevance for Pathophysiology by H. K. Kimelberg and A. A. Mongin		240
		Author Index		258
		Subject Index		259

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