Chemosensitivity (v. 1)

A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity, Volume 1: In Vitro Assays provides a panel of 16 in vitro measures of chemosensitivity in adherent and non-adherent cells for single agents and combinations of agents. In addition to immunohistochemical and imaging approaches, these assays include clonogenic, colorimetric, fluorometric, and physiological assays. Highlights include image analysis to assess drug sensitivity, high throughput approaches using green fluorescent protein, DIMSCAN (a microcomputer fluorescence-based assay), and the ChemoFx assay used in biotechnology. A companion volume, Volume 2: In Vivo Models, Imaging, and Molecular Regulators, provides protocols for classifying tumors into response categories and customizing chemotherapy regimens to individual patients.

ISBN 1588293459   Part volume In Vitro Assays ISBN13 9781588293459 (What's this?)   Volumes 1 Publisher Humana Press Inc.   Weight (grammes) 1160 Imprint Humana Press Inc.   Published in Totowa, NJ Format Hardback   Series ISSN 110- Publication date 14 Feb 2005   Series title Methods in Molecular Medicine Non-book description 2 v. :   Height (mm) 234 Library of Congress 2004012494   Width (mm) 156 DEWEY 616.994061   Spine width (mm) 15 DEWEY edition DC22   Academic level Professional / Scholarly Pages 244

Part I. Overview An Overview of Chemosensitivity Testing Rosalyn D. Blumenthal Part II. In Vitro Measures of Chemosensitivity Clonogenic Cell Survival Assay Anupama Munshi, Marvette Hobbs, and Raymond E. Meyn High-Sensitivity Cytotoxicity Assays for Nonadherent Cells M. Jules Mattes Sulforhodamine B Assay and Chemosensitivity Wieland Voight Use of the Differential Staining Cytotoxicity Assay to Predict Chemosensitivity Gertjan J. L. Kaspers Collagen Gel Droplet Culture Method to Examine In Vitro Chemosensitivity Hisayuki Kobayashi The MTT Assay to Evaluate Chemosensitivity Jack D. Burton Histoculture Drug Response Assay to Monitor Chemoresponse Shinji Ohie, Yasuhiro Udagawa, Daisuke Aoki, and Shiro Nozawa In Vitro Testing of Chemosensitivity in Physiological Hypoxia Rita Grigoryan, Nino Keshelava, Clarke Anderson, and C. Patrick Reynolds Chemosensitivity Testing Using Microplate Adenosine Triphosphate-Based Luminescence Measurements Christian M. Kurbacher and Ian A. Cree High-Throughput Technology: Green Fluorescent Protein to Monitor Cell Death Marylene Fortin, Ann-Muriel Steff, and Patrice Hugo DIMSCAN: A Microcomputer Fluorescence-Based Cytotoxicity Assay for Preclinical Testing of Combination Chemotherapy Nino Keshelava, TomasA Frgala, Jir-- i Krejsa, Ondrej Kalous, and C. Patrick Reynolds The ChemoFx(R) Assay: An Ex Vivo Cell Culture Assay for Predicting Anticancer Drug Responses Robert L. Ochs, Dennis Burholt, and Paul Kornblith Evaluating Response to Antineoplastic Drug Combinations in Tissue Culture Models C. Patrick Reynolds and Barry J. Maurer Image Analysis Using the Fluochromasia Assay to Quantify Tumor Drug Sensitivity John F. Gibbs, Youcef M. Rustum, and Harry K. Slocum Immunohistochemical Detection of Ornithine Decarboxylase as a Measure of Chemosensitivity Uriel Bachrach Immunohistochemistry of p53, Bcl-2 and Ki-67 as Predictors of Chemosensitivity Mitsuyoshi Itaya, Jiro Yoshimoto, Kuniaki Kojima, and Seiji Kawasaki Index

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