Cognitive Impairment and Dementia in Parkinson's Disease

Parkinson's disease has long been perceived as a pure motor disorder, partly due to its initial description by James Parkinson, who suggested that "senses and intellect remain intact", and partly due to the fact that patients with PD did not survive long, before effective treatment became available. As the survival time of patients with Parkinson's disease has substantially increased due to modern treatment, it has become apparent that cognitive deficits and dementia are also frequent features, especially in elderly patients. With the progression of the disease and age, dementia develops in a substantial number of patients and constitutes a major therapeutic challenge. Dementia has thus increasingly been the focus of research and practice in recent years and a large body of knowledge has been accumulated. Despite these developments there has been no single volume dedicated to this topic. This book provides an extensive overview of the current status of knowledge pertaining to cognitive impairment and dementia associated with Parkinson's disease, intended as a reference book for general neurologists, neurology residents and also those with a special interest in movement disorders. In this edited volume experts in the field describe in detail all aspects of cognitive impairment and dementia in Parkinson's disease, including epidemiology, spectrum of clinical features, pathology, neurochemistry and genetics, findings in auxiliary investigations, relation to other neurodegenerative disorders, diagnostic process and management, and rounded up by discussion of future research directions and expectations. The text is complemented and enriched with tables, figures and heavily referenced to encompass all relevant literature.

ISBN 0199564116   Pages 288 ISBN13 9780199564118 (What's this?)   Weight (grammes) 646 Publisher Oxford University Press   Published in Oxford Imprint Oxford University Press   Height (mm) 252 Format Hardback   Width (mm) 178 Publication date 07 Jan 2010   Spine width (mm) 20 DEWEY 616.833   Academic level Professional / Scholarly DEWEY edition DC22

1		Introduction by Murat Emre		1
2		Epidemiology of dementia associated with Parkinson's disease by Dag Aarsland		5
3		General features, mode of onset and course of dementia in Parkinson's disease by Murat Emre		15
4		Cognitive profile in Parkinson's disease dementia by Kolbjorn Bronnick		27
5		Neuropsychiatric symptoms in Parkinson's disease dementia by Daniel Weintraub and Eugenia Mamikonyan		45
6		Interaction between affect and executive functions in Parkinson's disease by Paolo Barone and Gabriella Santangelo		65
7		Motor symptoms and phenotype in patients with Parkinson's disease dementia by David J. Burn		75
8		Interaction between cognition and gait in patients with Parkinson's disease by J. M. Hausdorff and G. Yogev-Seligman and M. Plotnik and A. Mirelman and N. Giladi		87
9		Disorders of sleep and autonomic function in Parkinson's disease dementia by Eduardo Tolosa and Alex Iranzo		101
10		Neuroimaging in patients with Parkinson's disease dementia by Michael J. Firbank and John T. O'Brien		115
11		Electrophysiological and other auxiliary investigations in patients with Parkinson's disease dementia by Yasuyuki Okuma and Yoshikuni Mizuno		129
12		Genetic basis of dementia in Parkinson's disease by Rita Guerreiro and Andrew Singleton		141
13		Neurochemical pathology of Parkinson's disease dementia by Margaret Ann Piggott and Elaine K. Perry		153
14		Pathological correlates of dementia in Parkinson's disease by Gonzalo J. Revuelta and Carol Lippa		171
15		Cognitive impairment in non-demented patients with Parkinson's disease by Elise Caccappolo and Karen Marder		179
16		Spectrum of Lewy body dementias: relationship of Parkinson's disease dementia to dementia with Lewy bodies by Clive Ballard and Dag Aarsland		199
17		Spectrum of disorders with parkinsonism and dementia by Jaime Kulisevsky and Javier Pagonabarraga		215
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...this book can also be thoroughly recommended to general neurologists The Lancet: Neurology

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