Concepts in Biotechnology

Adopting a unique approach, this novel textbook integrates science and business for an inside view on the biotech industry. Peering behind the scenes, it provides a thorough analysis of the foundations of the present day industry for students and professionals alike: its history, its tools and processes, its markets and products. The authors, themselves close witnesses of the emergence of modern biotechnology from its very beginnings in the 1980s, clearly separate facts from fiction, looking behind the exaggerated claims made by start-up companies trying to attract investors. Essential reading for every student and junior researcher looking for a career in the biotech sector.

ISBN 352731766X   Pages 498 ISBN13 9783527317660 (What's this?)   Volumes 001 Publisher Wiley-VCH Verlag GmbH   Weight (grammes) 948 Imprint Wiley-VCH Verlag GmbH   Published in Weinheim Format Paperback   Height (mm) 240 Publication date 15 Dec 2010   Width (mm) 174 Library of Congress HD9999   Spine width (mm) 26 DEWEY 338.476606   Academic level Undergraduate, Postgraduate, Professional / Scholarly DEWEY edition DC22

Preface. Abbreviations and Glossary. Part One. History. 1. Introduction. 2. The Early Period to 1850. 2.1 Introduction. 2.2 Experimental Scientific Findings. 2.3 Application. 2.4 Theoretical Approaches. References. 3. The Period from 1850 to 1890. 3.1 Introduction. 3.2 Experimental Findings. 3.3 Practical Application, Technical Progress and Institutional Development. 3.4 Theoretical Approaches. References. 4. The Period from 1890 to 1950. 4.1 Introduction. 4.2 Research - Advances in the Basics of Biotechnology: Experimental Findings. 4.3 Technological Development, Progress and Application. 4.4 Theoretical Approaches. References. 5. Outlook, from 1950 Onwards: Biotechnology - Science or What? 5.1 Introduction. 5.2 Traditional Biotechnology and the Decehma Report. 5.3 The Changing Focus in BT in the USA in the Early 1980s. 5.4 Conclusions. References. Part Two The New Paradigm Based on Molecular Biology and Genetics. 6. Broadening of Biotechnology through Understanding Life, Genetics and Evolution. References. 7. The Beginning of the New Biotechnology. 7.1 Introduction. 7.2 The Beginnings of Evolution Theory and Genetics. 7.3 The Origin of Recombinant DNA Technology. 7.4 Oligonucleotide Synthesis Leads to Protein Engineering. 7.5 Synthetic DNA, Reverse Transciptase: Isolating Genes. 7.6 Biodiversity and Gene Mining. 7.7 Creating New Diversity by Design or Empirically. 7.8 'Genetic Fingerprinting'. 7.9 Inheritable Predisposition to Disease. References. 8. Ethical Aspects Related to Genome Research, and Reproductive Medicine. 8.1 Negative Public Reaction to Gene Technology. 8.2 Ethical Aspects: Animal Cloning and Fertility Research. References. 9. Elucidating Protein Structure: The Beginnings of Rational Protein Design. 9.1 Cambridge England, the Cradle of Structural Analysis of Macromolecules. 9.2 Redesigning the Protein Core. 9.3 Redesigning the Protein by Altering Primary Sequence. 9.4 Post Translational Modifications. 9.5 Total Chemical Synthesis. 9.6 Validation of Drug Design Based on the known Structure of the Target. 9.7 General Considerations in Drug Development. References. 10. The Development of Antibodies as Pharmaceutical Products. 10.1 An Introduction to the Immune System. 10.2 The Beginnings of Applied Immunology. 10.3 Monoclonal Antibodies. 10.4 Producing Antibodies via rDNA and Combinatorial Biology. 10.5 Affinity Enrichment on Surface of Immobilized Target Molecules. 10.6 Mice with Human Antibody Gene Repertoires. 10.7 Two Severe Setbacks during Clinical Testing. 10.8 A Survey of Therapeutic Antibodies. References. 11. Hereditary Disease and Human Genome Analysis. 11.1 Introduction. 11.2 Heredity Studies and Family Counselling . 11.3 Early Attempts to Analyse the Human Genome. 11.4 The Personalized Genome and Personal Medicine. 11.5 Analysing the Effect of the Environment on the Human Genome: Epigenetics. References. 12. Transgenic Animals and Plants. 12.1 Introduction. 12.2 Stem Cells and Gene Targeting. References. 13. Extrapolating to the Future. 13.1 Summary of the Status Quo. 13.2 Insect Control Through 'Sterile' Males (SIT). 13.3 The Future of Gene Therapy. 13.4 Stem Cell Therapy. 13.5 Flash Sequencing DNA: A Human Genome Sequence in Minutes? 13.6 Systems Biology and Looking for 'Druggable' Targets. 13.7 Synthetic Biology. References. 14. Biotechnology and Intellectual Property. 14.1 Introduction. 14.2 Patents Ensure Growth and Rapid Dissemination of Knowledge. 14.3 Owning a Patent does not simply Mean that it can be Implemented: "Freedom to Operate' (FTO). 14.4 Life-forms as 'Novel Subject Matter' for Patents? 14.5 Technology "State of the Art': Precedence/Directives, not Fixed by Law. 14.6 Who can make Decisions about Public Morality? 14.7 Biotechnology-oriented Directives Guide Patenting Decisions. References. Part Three. Application. 15. Bioprocess Engineering. 15.1 Introduction. 15.2 Aspects of Applied Microbiology. 15.3 Biocatalysis. 15.4 Biochemical Engineering. 15.5 Process Sustainability and Ecologi

"Summing Up: Recommended. Graduate students and above." (Choice, 1 September 2011)

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