Crystallization of Organic Compounds

Filled with industrial examples emphasizing the practical applications of crystallization methodologies Based on the authors' hands-on experiences as process engineers at Merck, Crystallization of Organic Compounds guides readers through the practical aspects of crystallization. It uses plenty of case studies and examples of crystallization processes, ranging from development through manufacturing scale-up. The book not only emphasizes strategies that have been proven successful, it also helps readers avoid common pitfalls that can render standard procedures unsuccessful. The goal of this text is twofold: * Build a deeper understanding of the fundamental properties of crystallization as well as the impact of these properties on crystallization process development. * Improve readers' problem-solving abilities by using actual industrial examples with real process constraints. Crystallization of Organic Compounds begins with detailed discussions of fundamental thermodynamic properties, nucleation and crystal growth kinetics, process dynamics, and scale-up considerations. Next, it investigates modes of operation, including cooling, evaporation, anti-solvent, and reactive crystallization. The authors conclude with special applications such as ultrasound in crystallization and computational fluid dynamics in crystallization. Most chapters feature multiple examples that guide readers step by step through the crystallization of active pharmaceutical ingredients (APIs). With its focus on industrial applications, this book is recommended for chemical engineers and chemists who are involved with the development, scale-up, or operation of crystallization processes in the pharmaceutical and fine chemical industries.

ISBN 0471467804   Pages 300 ISBN13 9780471467809 (What's this?)   Volumes 1 Publisher John Wiley and Sons Ltd   Weight (grammes) 692 Imprint Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)   Published in Chicester Format Hardback   Height (mm) 232 Publication date 26 Feb 2008   Width (mm) 162 Library of Congress 2008042950   Spine width (mm) 23 DEWEY 615.19   Academic level Tertiary education, Professional / Scholarly DEWEY edition DC22   Alternative ISBN 9780470447796

1		Introduction to Crystallization Issues		1
2		Properties		13
3		Polymorphism		49
4		Kinetics		77
5		Critical Issues in Crystallization Practice		101
6		Mixing and Crystallization		117
7		Cooling Crystallization		137
8		Evaporative Crystallization		167
9		Antisolvent Crystallization		179
10		Reactive Crystallization		207
11		Special Applications		235
		References		279
		Index		285

"For chemists and engineers working in process research and development, or even in production, this is the best book on crystallisation. For those in other disciplines, or in academia, wishing to get a perspective on industrial problems in crystallisation, polymorphism, salt formation etc and how to solve them, this would also be a valuable book ... I think they have achieved both of these goals admirably, and in a very readable and enjoyable format." (Organic Process, Research & Development Journal, 17 December 2010)

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