Fundamentals of Medicinal Chemistry

This work provides a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style. The title begins by reviewing the structures and nomenclature of the more common classes of naturally occurring compounds found in biological organisms. An overview of medicinal chemistry is followed by chapters covering the discovery and design of drugs, pharmacokinetics and drug metabolism. The book concludes with a chapter on organic synthesis, followed by a brief look at drug development from the research stage through to marketing the final product. The text assumes little in the way of prior biological knowledge. Relevant biology is included through biological topics, examples and the Appendices. It incorporates summary sections, examples, applications and problems. Each chapter contains an additional summary section and solutions to the questions are provided at the end of the text. It is invaluable for undergraduates studying within the chemical, pharmaceutical and life sciences.

ISBN 0470843071   Pages 302 ISBN13 9780470843079 (What's this?)   Volumes 1 Publisher John Wiley and Sons Ltd   Weight (grammes) 568 Imprint John Wiley & Sons Ltd   Published in Chichester Format Paperback   Height (mm) 248 Publication date 03 Oct 2003   Width (mm) 190 Library of Congress RS402.8   Spine width (mm) 16 DEWEY 615.19   Academic level Professional / Scholarly DEWEY edition DC22

		Preface
		Acknowledgements
		Abbreviations/Acronyms
1		Biological Molecules		1
2		An Introduction to Drugs and their Action		37
3		An Introduction to Drug Discovery		57
4		The SAR and QSAR Approaches to Drug Design		71
5		Computer Aided Drug Design		95
6		Combinatorial Chemistry		113
7		Selected Examples of Drug Action at some Common Target Areas		131
8		Pharmacokinetics		159
9		Drug Metabolism		181
10		An Introduction to Lead and Analogue Syntheses		203
11		Drug Development and Production		223
		Appendix		239
		Answers to Questions		261
		Selected Further Reading		273
		Index		275

"...it would be of great value to beginning graduate students in medicinal chemistry...it should be included in any practicing chemist's personal library." (Journal of Medicinal Chemistry, July 29, 2004) "Thomas presents the fundamentals of medicinal chemistry in a clear, concise, and descriptive fashion." (Choice, June 2004, Vol. 41 No. 10) "...provides a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style..." (www.organische-chemie.ch, 19/01/2004) "...well laid out, with an attractive typeface." (Chemistry and Industry, 6th September 2004)

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