Gene Regulation - A Eukaryotic Perspective

Gene regulation is an essential process in the development and maintenance of a healthy body, and as such, is a central focus in both basic science and medical research. "Gene Regulation, Fifth Edition" provides the student with a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview. For this edition, in addition to extensive updating of existing material, sections on large-scale methodologies have been expanded, and a new section included on regulation by small interfering RNAs. More detail has been added on the role of multi-protein complexes in transcriptional activation, and the discussion of the regulation of transcription factor activity by specific modifications, to include acetylation and ubiquitination, as well as phosphorylation. The final chapter on gene regulation and human disease now includes additional novel examples, such as RNA editing in motor neurone disease, role of the transcriptional co-activator CBP in Alzheimer's disease and PML-RAR involvement in acute promyelocytic leukaemia. Students in undergraduate courses will find this book essential reading.

ISBN 0415365104   Pages 374 ISBN13 9780415365109 (What's this?)   Volumes 1 Publisher Taylor & Francis Ltd   Weight (grammes) 812 Imprint Taylor & Francis Ltd   Published in London Format Paperback   Series title Advanced Texts Publication date 16 Jun 2005   Height (mm) 246 Library of Congress 2005009966   Width (mm) 178 DEWEY 572.865   Spine width (mm) 18 DEWEY edition DC22   Academic level Undergraduate, Postgraduate, Professional / Scholarly

1		Tissue-specific expression of proteins and messenger RNAs		1
2		The DNA of different cell types is similar in both amount and type		15
3		Gene expression		39
4		Regulation at transcription		79
5		Post-transcriptional regulation		99
6		Transcriptional control - chromatin structure		147
7		Transcriptional control - DNA sequence elements		203
8		Transcriptional control - transcription factors		243
9		Gene regulation and human disease		307
10		Conclusions and future prospects		357

 Be the first to write a customer review