Handbook of Nanoindentation

Nanoindentation is ideal for the characterization of inhomogeneous biological materials. However, the use of nanoindentation techniques in biological systems is associated with some distinctively different techniques and challenges. For example, engineering materials used in the microelectronics industry (e.g. ceramics and metals) for which the technique was developed, are relatively stiff and exhibit time-independent mechanical responses. Biological materials, on the other hand, exhibit time-dependent behavior, and can span a range of stiffness regimes from moduli of Pa to GPa i??i?? eight to nine orders of magnitude. As such, there are differences in the selection of instrumentation, tip geometry, and data analysis in comparison with the i??degreeblack boxi??i?? nanoindentation techniques as sold by commercial manufacturers. The use of scanning probe equipment (atomic force miscroscopy) is also common for small-scale indentation of soft materials in biology. The book is broadly divided into two parts. The first part presents the i??degreebasic sciencei??i?? of nanoindentation including the background of contact mechanics underlying indentation technique, and the instrumentation used to gather mechanical data. Both the mechanics background and the instrumentation overview provide perspectives that are optimized for biological applications, including discussions on hydrated materials and adaptations for low-stiffness materials. The second part of the book covers the applications of nanoindentation technique in biological materials. Included in the coverage are mineralized and nonmineralized tissues, wood and plant tissues, tissue-engineering substitute materials, cells and membranes, and cutting-edge applications at molecular level including the use of functionalized tips to probe specific molecular interactions (e.g. the ligand-receptor binding). The book concludes with a concise summary and an insightful forecast of the future highlighting the current challenges.

ISBN 981424189X   Pages 358 ISBN13 9789814241892 (What's this?)   Volumes 1 Publisher Pan Stanford Publishing Pte Ltd   Weight (grammes) 839 Imprint Pan Stanford Publishing Pte Ltd   Published in Singapore Format Hardback   Height (mm) 254 Publication date 15 Oct 2010   Width (mm) 178 DEWEY 620.5   Spine width (mm) 23 DEWEY edition DC22   Academic level Postgraduate

		Preface
Chapter 1		Introduction by Michael F. Ashby		1
Chapter 2		Indentation and Adhesion at Small Length Scales by Robert F. Cook		23
Chapter 3		Instrumentation and Experimentation by Krystyn J. Van Vliet		39
Chapter 4		Mechanics of Adhesion by Robert F. Cook		77
Chapter 5		Mechanics of Indentation by Michelle L. Oyen		123
Chapter 6		Computational Modeling of Indentation by Xi Chen		153
Chapter 7		Nanoindentation of Bone by Sara E. Olesiak		185
Chapter 8		Nanoindentation of Tooth Tissues by Michael V. Swain		239
Chapter 9		Nanoindentation of Soft Tissues and Other Biological Materials by Donna M. Ebenstein		279
Chapter 10		Cells and Membranes by Kai-Tak Wan		325
Chapter 11		Conclusions and Outlook by Michelle L. Oyen		351
		Index		357

"Michelle Oyen has done a superb job compiling experts in the field of nanoindentation. This book spans a wide variety of topics ranging from the fundamental theory and instrumentation of nanoindentation to its application in biological materials including soft tissues, mineralized tissues, and cell structures. This book is an excellent resource for students and researchers alike." --Professor Lisa Pruitt, University of California, Berkeley, USA

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