Hematopoietic Stem Cell Transplantation Research Advances

Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (that is, bone marrow transplantation) or blood. Stem cell transplantation is a medical procedure in the fields of hematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer. Stem cell transplantation was pioneered using bone-marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognized with a Nobel Prize in Physiology and Medicine.Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells. His work also reduced the likelihood of developing a life-threatening complication called Graft-versus-host disease. With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoeitic stem cell transplantation procedures are now performed using stem cells collected from the peripheral blood, rather than from the bone marrow. Collecting stem cells provides a bigger graft, and does not require that the donor be subjected to general anesthesia to collect the graft. Hematopoeitic stem cell transplantation remains a risky procedure with many possible complications; it has always been reserved for patients with life-threatening diseases. This book presents recent leading research in the field.

ISBN 1604560428   DEWEY edition DC22 ISBN13 9781604560428 (What's this?)   Pages 248 Publisher Nova Science Publishers Inc   Volumes 001 Imprint Nova Science Publishers Inc   Published in New York Format Hardback   Height (mm) 260 Publication date 01 Mar 2008   Width (mm) 180 Library of Congress RD123.5   Academic level Professional / Scholarly DEWEY 617.440592

Commentary A		Mannan-Binding Lectin and Stem Cell Transplantation by David C. Kilpatrick		1
Commentary B		Sexuality of Men Treated by Means of Haematopoietic Stem Cell Transplantation by Ladislav Slovacek and Birgita Slovackova		7
		Research and Review Articles
Ch. I		Bone Marrow-Derived Stem Cells: Homing and Rescue of Injury in the Lung by Donatella Piro and Silvia Lepore and Angela Bruna Maffione and Massimo Conese		15
Ch. II		Role of Platelet Derived Factors for the Protection Against Graft-Versus-Host Disease by Tsuyoshi Iwasaki		45
Ch. III		The Evolving Role of Hematopoietic Stem Cell Transplantation in Non-Hodgkin Lymphoma by Koji Kato and Smitha Mellacheruvu and Shin Mineishi		71
Ch. IV		Stem Cell Plasticity by Suraksha Agrawal and Piyush Tripathi and Sita Naik		109
Ch. V		Dental Management before Hematopoietic Stem Cell Transplantation for Adult and Pediatric Patients with Hematological Disease by Kenji Yamagata and Kojiro Onizawa and Hiroshi Yoshida		155
Ch. VI		Haematopoietic Stem Cell Transplantation and Quality of Life by Ladislav Slovacek and Birgita Slovackova		175
Ch. VII		Risk Factors for Survival in Pediatric Patients Undergoing Allogeneic Cord Blood Transplantation by Marta Gonzalez-Vicent and Julian Sevilla and Alvaro Lassaletta and Manuel Ramirez and Luis Madero and Miguel A. Diaz		199
Ch. VIII		Multipoptent Mesenchymal Stromal Cells for Skin Wound Healing and Skeletal Muscle Repair by Ying Zhu and Chunmeng Shi and Xinze Ran and Yongping Su and Chengji Luo and Tianmin Cheng		215
		Index		229

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