Histone Deacetylases

A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes - both alone and in complex with small molecule inhibitors - and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.

ISBN	1588294994	Pages	352
ISBN13	9781588294999 (What's this?)	Volumes	1
Publisher	Humana Press Inc.	Weight (grammes)	767
Imprint	Humana Press Inc.	Published in	Totowa, NJ
Format	Hardback	Series title	Cancer Drug Discovery & Development
Publication date	05 Jan 2006	Height (mm)	229
Non-book description	xi, 340 p. :	Width (mm)	152
Library of Congress	2005031537	Spine width (mm)	25
DEWEY	616.994061	Academic level	Professional / Scholarly
DEWEY edition	DC22

I	Class I histone deacetylases
1	Histone deacetylase 1 by Dominique Meunier and Christian Seiser	3
2	Biochemistry of multiprotein HDAC complexes by Alejandro Vaquero and Michael Scher and Danny Reinberg	23
3	The biology of HDAC3 by Edward Seto	61
4	The biology of HDAC8, a unique class I histone deacetylase by David Waltregny and Vincent Castronovo	87
II	Class II histone deacetylases
5	Regulation of muscle gene expression by histone deacetylases by Timothy A. McKinsey and Eric N. Olson	107
6	The class IIa histone deacetylases : functions and regulation by Herbert G. Kasler and Eric Verdin	129
7	Histone deacetylases in the response to misfolded proteins by J. Andrew McKee and Tso-Pang Yao	165
III	Class III histone deacetylases
8	Evolution of sirtuins from archaea to vertebrates by Roy A. Frye	183
9	Structure of the Sir2 family of NAD[superscript +]-dependent histone/protein deacetylases by Kehao Zhao and Ronen Marmostein	203
10	The enzymology of SIR2 proteins by Margie T. Borra and John M. Denu	219
11	The class III protein deacetylases : homologs of yeast Sir2p by Bjoern Schwer and Brian J. North and Nidhi Ahuja and Brett Marshall and Eric Verdin	237
12	HDAC inhibitors : discovery, development, and clinical impacts by Akihiro Ito and Norikazu Nishino and Minoru Yoshida	271
13	Cell cycle targets of histone deacetylase inhibitors by Brian Gabrielli	299
14	HDAC inhibitors : an emerging anticancer therapeutic strategy by Paul Kwon and Meier Hsu and Dalia Cohen and Peter Atadja	315

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Transcriptional Regulation and Other Cellular Functions

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