Infectious Disease Informatics

This book will be the first to leverage on recent breakthroughs in the rapid, high-throughput molecular profiling of pathogenic microorganisms, as well as text mining and the growing body of electronic sources of knowledge about the molecular epidemiology of pathogens with epidemic potential. The distinctive feature of this book is that its focus on bioinformatics enabled approaches to pathogen detection, investigation and management of infections. This volume also details new methods of analyzing the genetic and geographic data of pathogens to reconstruct their evolution and to identify the migration routes through which the strains spread regionally and internationally. This book will fill the existing gap in covering the bioinformatics aspects of infectious diseases and will complement numerous successful bioinformatics texts devoted to the mainstream of human genetics and cancer.

ISBN 1441913262   Pages 446 ISBN13 9781441913265 (What's this?)   Weight (grammes) 912 Publisher Springer-Verlag New York Inc.   Published in New York, NY Imprint Springer-Verlag New York Inc.   Height (mm) 235 Format Hardback   Width (mm) 155 Publication date 21 Dec 2009   Spine width (mm) 30 DEWEY 616.9   Academic level Professional / Scholarly DEWEY edition DC22

Preface.- List of contributors.- 1 Informatics for Infectious Disease Research and Control.- 2 Bioinformatics of Microbial Sequences.- 3 Mining Databases for Microbial Gene Sequences.- 4 Comparative Genomics of Pathogens.- 5 Systems Microbiology: Gaining Insights in Transcriptional Networks.- 6 Host-Pathogen Systems Biology.- 7 Text Mining for Discovery of Host-Pathogen Interactions.- 8 A Network Approach to Understanding Pathogen Population Structure: from Host Networks to Antigen Networks.- 9 Computational Epitope Mapping.- 10 Pangenomic Reverse Vaccinology.- 11 Immunoinformatics: The Next Step in Vaccine Design.- 12 Understanding the Shared Bacterial Genome.- 13 Computational Grammars for Annotation and Interrogation of Mobile Genetic Elements.- 14 In silico Discovery of Chemotherapeutic Agents.- 15 Informatics for Healthcare Epidemiology.- 16 Automated, High-throughput Surveillance Systems for Public Health.- 17 Microbial Genotyping Systems for Infection Control.- 18 Temporal and Spatial Clustering of Bacterial Genotypes.- 19 Infectious Disease Ontology.- 20 Populations, patients, germs and genes -- ethics of genomics and informatics in communicable disease control.- Glossary.

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