Mass Spectrometry

The latest edition of a highly successful textbook, Mass Spectrometry, Third Edition provides students with a complete overview of the principles, theories and key applications of modern mass spectrometry. All instrumental aspects of mass spectrometry are clearly and concisely described: sources, analysers and detectors. Tandem mass spectrometry is introduced early on and then developed in more detail in a later chapter. Emphasis is placed throughout the text on optimal utilisation conditions. Various fragmentation patterns are described together with analytical information that derives from the mass spectra. This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: Increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications. Mass Spectrometry, Third Edition is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments.

ISBN 0470033118   Pages 502 ISBN13 9780470033111 (What's this?)   Volumes 1 Publisher John Wiley and Sons Ltd   Weight (grammes) 838 Imprint Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)   Published in Chicester Format Paperback   Previous ISBN 9780471485667 Publication date 21 Sep 2007   Height (mm) 244 Library of Congress QD96   Width (mm) 170 DEWEY 543.65   Spine width (mm) 28 DEWEY edition DC22   Academic level Professional / Scholarly

Contents Preface Introduction Principles Diagram of a Mass Spectrometer History Ion Free Path 1 Ion Sources 1.1 Electron Ionization 1.2 Chemical Ionization 1.2.1 Proton transfer 1.2.2 Adduct formation 1.2.3 Charge-transfer chemical ionization 1.2.4 Reagent gas 1.2.5 Negative ion formation 1.2.6 Desorption chemical ionization (DCI) 1.3 Field Ionization 1.4 Fast Atom Bombardment and Liquid Secondary Ion Mass Spectrometry 1.5 Field Desorption 1.6 Plasma Desorption 1.7 Laser Desorption 1.8 Matrix-Assisted Laser Desorption Ionization 1.8.1 Principle of MALDI 1.8.2 Practical considerations 1.8.3 Fragmentations 1.8.4 Atmospheric pressure matrix-assisted laser desorption ionization 1.9 Thermospray 1.10 Atmospheric Pressure Ionization 1.11 Electrospray 1.11.1 Multiply charged ions 1.11.2 Electrochemistry and electric field as origins of multiply charged ions 1.11.3 Sensitivity to concentration 1.11.4 Limitation of ion current from the source by the electrochemical process 1.11.5 Practical considerations 1.12 Atmospheric Pressure Chemical Ionization 1.13 Atmospheric Pressure Photoionization (APPI) 1.14 Atmospheric Pressure Secondary Ion Mass Spectrometry (APSIMS) 1.14.1 Desorption electrospray ionization (DESI) 1.14.2 Direct analysis in real time (DART) 1.15 Inorganic Ionization Sources 1.15.1 Thermal ionization source 1.15.2 Spark source 1.15.3 Glow discharge source 1.15.4 Inductively coupled plasma source 1.15.5 Practical considerations 1.16 Gas-Phase Ion-Molecule Reactions 1.17 Formation and Fragmentation of Ions: Basic Rules 1.17.1 Electron ionization and photoionization under vacuum 1.17.2 Ionization at low pressure or at atmospheric pressure 1.17.3 Proton transfer 1.17.4 Adduct formation 1.17.5 Formation of aggregates or clusters 1.17.6 Reactions at the interface between source and analyzer 2 Mass Analyzers 2.1 Quadrupole Analyzers 2.1.1 Description 2.1.2 Equations of motion 2.1.3 Ion guide and collision cell 2.1.4 Spectrometers with several quadrupoles in tandem 2.2 Ion Trap Analyzers 2.2.1 Three-dimensional ion trap 2.2.2 Two-dimensional ion trap 2.3 The Electrostatic Trap or "Orbitrap" 2.4 Time-of-Flight Analyzers 2.4.1 Linear time-of-flight mass spectrometer 2.4.2 Delayed pulsed extraction 2.4.3 Reflectrons 2.4.4 Tandem mass spectrometry with time-of-flight analyzer 2.4.5 Orthogonal acceleration time-of-flight instruments 2.5 Magnetic and Electromagnetic Analyzers 2.5.1 Action of the magnetic field 2.5.2 Electrostatic field 2.5.3 Dispersion and resolution 2.5.4 Practical considerations 2.5.5 Tandem mass spectrometry in electromagnetic analyzers 2.6 Ion Cyclotron Resonance and Fourier Transform Mass Spectrometry 2.6.1 General principle 2.6.2 Ion cyclotron resonance 2.6.3 Fourier transform mass spectrometry 2.6.4 MSn in ICR/FTMS instruments 2.7 Hybrid Instruments 2.7.1 Electromagnetic analyzers coupled to quadrupoles or ion trap 2.7.2 Ion trap analyzer combined with time-of-flight or ion cyclotron resonance 2.7.3 Hybrids including a time-of-flight with orthogonal acceleration 3 Detectors and Computers 3.1 Detectors 3.1.1 Photographic plate 3.1.2 Faraday cup 3.1.3 Electron multipliers 3.1.4 Electro-optical ion detectors 3.2 Computers 3.2.1 Functions 3.2.2 Instrumentation 3.2.3 Data acquisition 3.2.4 Data conversion 3.2.5 Data reduction 3.2.6 Library search 4 Tandem Mass Spectrometry (MS/MS)

"This is a great book for everyone in the field to keep handy." (CHOICE, April 2008) "Overview of the principles, theories, and key applications of modern mass spectrometry." (Materials and Corrosion, November 2007)

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