Mechanisms and Consequences of Proton Transport

The principal focus of "Mechanisms and Consequences of Proton Transport" is on the gastric parietal cell and the acid secretory apparatus: how it operates and the consequences of malfunction. The key topics include: the fundamental structure and molecular operation of the gastric H+/K+ exchange pump; gene targeting studies directed at functional changes in the gastric epithelium and its ability to deal with the pathological consequences of acid and Helicobacter pylori infection; and regulation of parietal cell activation by protein kinases and ion transport pathways; the parietal cell as a model to study mechanisms for the translocation, docking, and fusion of membranes associated with regulated recruitment and recycling of transport proteins. This book provides cutting edge research for physiologists, cell biologists, and gastroenterologists who wish to understand the mechanisms of the gastric proton pump and the consequences of malfunction and pathology.

ISBN 1402070594   DEWEY edition DC21 ISBN13 9781402070594 (What's this?)   Pages 392 Publisher Kluwer Academic Publishers   Volumes 1 Imprint Kluwer Academic Publishers   Weight (grammes) 813 Format Hardback   Published in Dordrecht Publication date 01 Jul 2002   Height (mm) 235 Library of Congress 02018650   Width (mm) 155 DEWEY 571.64   Academic level Professional / Scholarly

		Preface
1		The Gastric H,K-ATPase by O. Vagin and K. Munson and J. M. Shin		1
2		Human Nongastric H,K-ATPase: Current View On Structure and Functional Properties by G. Adams and M. Tillekeratne and N. B. Pestov		19
3		Functional Consequences of Subunit Interactions in Na,K- and H,K-ATPases by G. Crambert and P. Beguin and U. Hasler		33
4		HKc[alpha] Encodes Ouabain-Insensitive H,K-ATPase in Surface Cells of Rat Distal Colon by H. J. Binder		43
5		Molecular Diversity and Regulatory Heterogeneity of H,K-ATPases in Kidney by T. D. Dubose, Jr. and J. Codina and J. Li		53
6		Mutational Analysis of Gastric Proton Pump, [alpha]- and [beta]-Subunits by S. Asano and T. Kimura and N. Takeguchi		59
7		Structure-Activity Relationships of Na,K-ATPase and H,K-ATPase by J. J. H. H. M. De Pont and J. B. Koenderink and H. G. P. Swarts		71
8		The Effect of Mutations Within a Cluster of Homologous Amino Acids Present in the M5, M6 and M8 Transmembrane Regions of the H,K-ATPase by E. C. Rabon and S. J. Rulli and E. V. Skripnikov		83
9		Host-Specific H. pylori Inhibition of H,K-ATPase [alpha] Subunit Gene Expression by A. Smolka and M. Gooz		91
10		H[superscript +],K[superscript +]-ATPase, the Dominant Gastric Autoantigen In Helicobacter pylori Infection by B. J. Appelmelk and M. P. Bergman and A. V. D. Aar		101
11		The Gastric H/K ATPase in the Pathogenesis of Autoimmune Gastritis by B.-H. Toh and M. Biondo and A. Marshall		107
12		Duodenal Protection: Influence of Melatonin and Other Intestinal Transmitters on Duodenal Bicarbonate Secretion and Enterocyte Signaling by G. Flemstrom and M. Sjoblom		115
13		Role of Cytokines in Helicobacter pylori-Induced Gastric Epithelial Cell Matrix Metalloproteinase Secretion and Activation by M. Gooz and M. Shaker and P. Gooz		123
14		HCI Causes Less Intracellular Acidification in Surface Epithelial Cells of Isolated Necturus Gastric Mucosa than Other Inorganic Acids by T. Kiviluoto and O. Nylander-Koski and H. Mustonen		127
		More...
		Index		365

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