Molecular Diagnostics

Provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. It takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, clinical trial methodology, and the future of personalized cancer medicine.

ISBN 981424144X   Pages 351 ISBN13 9789814241441 (What's this?)   Volumes 1 Publisher Pan Stanford Publishing Pte Ltd   Weight (grammes) 703 Imprint Pan Stanford Publishing Pte Ltd   Published in Singapore Format Hardback   Height (mm) 229 Publication date 15 Apr 2010   Width (mm) 152 DEWEY 616.994075   Spine width (mm) 20 DEWEY edition DC22   Academic level Postgraduate, Professional / Scholarly

		Introduction
		Developing Molecular Diagnostics in Cancer by Jan Trost Jorgensen		1
		The Estrogen and Progesterone Receptors---Setting the Scene for Pharmacodiagnostics by Kwok-Leung Cheung		21
		The Development of the HercepTest™---From Bench to Bedside by Henrik Winther		43
		Predictive Biomarkers and Translational Cancer Medicine by Nils Brunner		61
		Pharmacodiagnostic Testing---Immunohistology by Trishe Y.-M. Leong		87
		In Situ Hybridisation for Pharmacodiagnostic Testing by Fiona M. Campbell		119
		MammaPrint® Translating Research into a Diagnostic Test by Oscar Krijgsman		139
		DNA Biomarkers in the Diagnosis and Management of Cancer by Per Guldberg		165
		Validating the Analytical Power and Parameteres of an Immunohistochemical Test by Soren Nielsen		185
		Drug and Pharmacodiagnostic Co-Development: Statistical Considerations by Richard Simon		207
		Clinical Validation of Biomarkers in Cancer by Daniel J. Sargent		227
		Pharmacogenomic Markers for Cancer Therapy by Sharon Marsh		251
		Safety and Effective Biomarkers in Oncology---A Regulatory Drug and Device Perspective by Francis Kalush		275
		Personalizing Treatment Selection for Breast Cancer by Chit Cheng Yeoh		297
		Pharmacodiagnostics and Personalized Medicine in Cancer by Jan Trøst Jorgensen		325

"The editors have recruited a highly experienced group of both academic medical center and industry-based international authors and produced a concise yet thorough overview of the emerging field of integrated diagnostics and personalized medicine. This book emphasizes slide-based companion pharmacodiagnostics, but also covers in depth post-extraction DNA sequence-based and mRNA profiling-based prognostic and predictive tests for both solid tumors and hematologic malignancies. Chapters on test development, regulatory approval and important consideration of test validation and clinical utility round out this impressive work. Not only will academic departments and cancer centers find this book to be an authoritative reference volume, but also the pharmaceutical and biotechnology industries will be able to gain considerable insight that could play a major role in the shaping of their current and future products." --Prof. Jeffrey S. Ross, Albany Medical College, USA "The topics and information covered in the book are the ones highly demanded in the current clinical biomarker sciences. This volume has successfully made a comprehensive coverage from all the experts in biomarker discovery, development, clinical trial and statistical validation, and practical use. This is definitely one of the references that everyone in this area should have." --Prof. Jae K. Lee, University of Virginia

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