Neuronal Death by Accident or by Design

Four chapters represent the intense current effort to understand the way in which the mitochondrion controls the activation of the final stages of cell death. Another four articles attack the problem from the other side. How do specific insults in particular human or mouse neuro-degenerative diseases translate into mechanisms that will not only allow us to better understand what is happening in these patients but also, with luck, allow for development of more efficient and specific drugs in the future? Firstly, the concept of a central common cell death pathway, originally derived from studies on the nematode, has been an outstanding productive paradigm in bringing together different strands of research. Secondly, truly striking links have been made between results obtained in the culture dish (or even cell-free systems) and the diseased human brain.

ISBN 354041777X   Pages 165 ISBN13 9783540417774 (What's this?)   Volumes 1 Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG   Weight (grammes) 451 Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K   Published in Berlin Format Hardback   Series editor Christen, Y. Publication date 25 Sep 2001   Series title Research and Perspectives in Neurosciences Library of Congress 2001042631   Height (mm) 235 DEWEY 616.80478   Width (mm) 155 DEWEY edition DC21   Academic level Undergraduate, Postgraduate, Professional / Scholarly

		Mitochondria and Apoptosis, the Stepping Stones on the Path to Death by D. W. Ethell and D. R. Green		1
		Mitochondrial Membrane Permeabilization in Physiological and Pathological Cell Death by L. Ravagnan and G. Kroemer		15
		Bcl-2 Family Members and Permeabilization of the Outer Mitochondrial Membrane by O. Terradillos and X. Roucou and S. Da Cruz		27
		Roles for Fas in Programmed Cell Death of Motoneurons by C. Raoul and G. Ugolini and A. Estevez		33
		Events that Commit Neurons to Die After Trophic Factor Deprivation by G. V. Putcha and M. Deshmukh and E. M. Johnson, Jr.		47
		Normal Programmed Cell Death of Developing Avian and Mammalian Neurons Following Inhibition or Genetic Deletion of Caspases by R. W. Oppenheim and C.-Y. Kuan and D. Prevette		61
		Caspases and Their Regulation in Apoptosis During Brain Development by C.-Y. Kuan and R. A. Flavell and P. Rakic		75
		Apoptotic Neurodegeneration in the Developing Brain by C. Ikonomidou		89
		Apoptosis, Glial Cells and Parkinson's Disease by E. C. Hirsch		97
		Mechanisms of Neuronal Death: An in vivo Study in the Lurcher Mutant Mice by F. Selimi and A. Campana and J. Bakouche		109
		Neuronal Death in Huntington's Disease: Multiple Pathways for One Issue? by S. Humbert and F. Saudou		137
		Subject Index		153

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