Oxford Textbook of Clinical Pharmacology and Drug Therapy

Revised and updated, this second edition retains its essential character. It aims to provide medical students and clinicians with an insight into why drugs have their therapeutic effects, by presenting the basic principles of pharmacology as they affect the human body - the patient. An understanding of these clinical pharmacological principles is essential for rational, safe, effective and economical prescribing. The text shows how knowledge of the scientific basis of drug action is applied in a clinical context to devise the most effective treatments for disease and to maximize the therapeutic effect of the drugs being used. Divided into four sections, this text provides details of adverse drug effects and interactions, pharmacogenetics, clinical trials, the discovery, development and marketing of drugs, drug treatment in the old and the young and the use of drugs in relation to reproduction and pregnancy. It also provides advice on practical matters of drug prescribing. Detailed descriptions of the practical management of diseases with drugs are given, emphasizing the integration of principles with practice. Lastly, a reference pharmacopoeia of over 300 commonly used drugs is presented, which includes details of their uses, modes of actions, pharmacokinetic properties, adverse efects and interacions, doses and regimens. For this edition the format of the original has been retained, but the basic science has been updated and edited to remove any theoretical discussion which is not essential to understanding the therapeutic process. The sections on pregnancy, reproduction and labour have been expanded and updated. The involvement of clinical specialists in the revision of the therapeutic chapters aims to ensure that the book reflects the best clinical practice in these disciplines. This text is aimed at medical students, students of pharmacy and applied pharmacology, nurses in training, newly qualified physicians and those in specialist post-graduate training.

ISBN 0192616765   DEWEY edition DC20 ISBN13 9780192616760 (What's this?)   Pages 774 Publisher Oxford University Press   Volumes 001 Imprint Oxford University Press   Weight (grammes) 1364 Format Hardback   Published in Oxford Publication date 01 Nov 1992   Height (mm) 240 Non-book description xviii756   Width (mm) 180 Library of Congress RM300.G715   Spine width (mm) 42 DEWEY 615.58   Academic level Undergraduate, Postgraduate, Professional / Scholarly

Sect. I		Clinical pharmacology: the scientific basis of drug therapy
1		The four processes of drug therapy		3
2		The pharmaceutical process: is the drug getting into the patient?		7
3		The pharmacokinetic process: is the drug getting to its site of action?		13
4		The pharmacodynamic process: is the drug producing the required pharmacological effect?		41
5		The therapeutic process: is the pharmacological effect being translated into an appropriate therapeutic effect?		55
6		Practical applications of the analysis of drug therapy		67
7		Monitoring drug therapy		79
8		Pharmacogenetics		94
9		Adverse reactions to drugs		104
10		Drug interactions		122
11		Drug therapy in young and old people		137
12		Drug therapy and reproduction		147
13		Patient compliance		162
14		Placebos		165
15		Drug discovery and development: the pharmaceutical industry and the regulatory authorities		167
16		Clinical trials		174
17		The drug history and the clinical examination and investigation of drug effects		190
Sect. II		Practical prescribing
18		Principles of prescribing		197
19		How to write a prescription		207
20		Sources of information on drugs		215
Sect. III		The drug therapy of disease
21		Introduction to drug therapy		225
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