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Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. It contains the latest information on the subject of neurodegenerative disorders. It reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems.
| ISBN | 0444528091 | | Pages | 794 | | ISBN13 | 9780444528094
(What's this?) | | Volumes | 1 | | Publisher | Elsevier Science & Technology | | Weight (grammes) | 1611 | | Imprint | Elsevier Science Ltd | | Published in | Oxford | | Format | Hardback | | Height (mm) | 240 | | Publication date | 22 Mar 2007 | | Width (mm) | 165 | | Library of Congress | RC | | Spine width (mm) | 38 | | DEWEY | 616.8047 | | Academic level | Professional / Scholarly | | DEWEY edition | DC22 | |
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| Ch. 1 | | Advances in our understanding of neurodegeneration by Kurt A. Jellinger | | 1 | | Ch. 2 | | Mitochondrial mutagenesis in the brain in forensic and pathological research by Nicole von Wurmb-Schwark | | 59 | | Ch. 3 | | Genetic and environmental factors in neurodegenerative diseases by Fabio Coppede and Lucia Migliore | | 89 | | Ch. 4 | | Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders by Vittorio Calabrese and Cesare Mancuso and Carlo De Marco and Anna Maria Giuffrida Stella and D. Allan Butterfield | | 115 | | Ch. 5 | | Oxidative stress and radiation-induced late normal tissue injury by M. E. C. Robbins and W. Zhao | | 135 | | Ch. 6 | | The cell cycle and oxidative neuronal cell death by Brett C. Langley | | 165 | | Ch. 7 | | Redox imbalance by Daniela Berg | | 183 | | Ch. 8 | | Genes and oxidative stress in sporadic and familial parkinsonism : cDNA microarray studies by E. Grunblatt and S. Mandel and P. Riederer and M. B. H. Youdim | | 201 | | Ch. 9 | | Down syndrome, antioxidant balance and the "gene dosage effect" hypothesis by J. B. de Haan and P. J. Crack and M. A. Pritchard and I. Kola | | 219 | | Ch. 10 | | The role of Levodopa in the chronic neurodegenerative disorder - Parkinson's disease by Thomas Muller | | 237 | | Ch. 11 | | Reactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients by K. Christou and K. I. Gourgoulianis | | 247 | | Ch. 12 | | The key role of oxidative stress in Alzheimer's disease by Paula I. Moreira and Akihiko Nunomura and Kazuhiro Honda and Gjumrakch Aliev and Gemma Casadesus and Xiongwei Zhu and Mark A. Smith and George Perry | | 267 | | Ch. 13 | | The role of oxidative stress in the pathogenesis of multiple sclerosis : current state by Nirit Lev and Yossi Gilgun-Sherki and Daniel Offen and Eldad Melamed | | 283 | | Ch. 14 | | Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis : from biology to therapeutic strategies by Molina Mhatre and Kenneth Hensley | | 297 | | Ch. 15 | | Oxidative stress in stroke by Margarita L. Alexandrova and Petyo G. Bochev | | 313 | | | More... | | |
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