Pharmacometrics

Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians. Edited and written by key leaders in the field, this flagship text on pharmacometrics: * Integrates theory and practice to let the reader apply principles and concepts. * Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field. * Is unique in including computer code information with the examples. This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies.

ISBN 0471677833   Pages 1216 ISBN13 9780471677833 (What's this?)   Volumes 1 Publisher John Wiley and Sons Ltd   Weight (grammes) 2264 Imprint Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)   Published in Chicester Format Hardback   Height (mm) 261 Publication date 08 May 2007   Width (mm) 183 Library of Congress 2006016629   Spine width (mm) 67 DEWEY 615.1   Academic level Professional / Scholarly DEWEY edition DC22   Alternative ISBN 9780470087978

1		Pharmacometrics : impacting drag development and pharmacotherapy by Paul J. Williams and Ene I. Ette		1
2		General principles of programming : computer and statistical by Sastry S. Isukapalli and Amit Roy		25
3		Validation of software for pharmacometric analysis by Gary L. Wolk		53
4		Linear, generalized linear and nonlinear mixed effects models by Farkad Ezzet and Jose C. Pinheiro		103
5		Bayesian hierarchical modeling with Markov chain Monte Carlo methods by Stephen B. Duffull and Lena E. Friberg and Chantaratsamon Dansirikul		137
6		Estimating the dynamics of drag regimen compliance by Ene I. Ette and Alaa Ahmad		165
7		Graphical displays for modeling population data by E. Niclas Jonsson and Mats O. Karlsson and Peter A. Milligan		183
8		The epistemology of pharmacometrics by Paul J. Williams and Yong Ho Kim and Ene I. Ette		223
9		Data imputation by Ene I. Ette and Hui-May Chu and Alaa Ahmad		245
10		Population pharmacokinetic estimation methods by Ene I. Ette and Paul J. Williams and Alaa Ahmad		265
11		Timing and efficiency in population pharmacokinetic/pharmacodynamic data analysis projects by Siv Jonsson and E. Nicks Jonsson		287
12		Designing population pharmacokinetic studies for efficient parameter estimation by Ene I. Ette and Amit Roy		303
13		Population models for drag absorption and enterohepatic recycling by Olivier Petricoul and Valerie Cosson and Eliane Fuseau and Mathilde Marchand		345
14		Pharmacometric knowledge discovery from clinical trial data sets by Ene I. Ette		383
15		Resampling techniques and their application to pharmacometrics by Paul J. Williams and Yong Ho Kim		401
16		Population modeling approach in bioequivalence assessment by Chuanpu Hu and Mark E. Sale		421
17		Biomarkers in drug development and pharmacometric modeling by Paul J. Williams and Ene I. Ette		457
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"...this landmark text is the first to pull together and present in one volume the many facets of pharmacometrics." (American Journal of Pharmaceutical Education, Vol 71, No. 4, 2007)

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