Physical Biology

Edited by Nobel Laureate, Ahmed Zewail, this pioneering book on physical biology includes contributions from four Nobel laureates and other eminent scientists. This book brings about the confluence of various concepts and tools to address significant problems of our time in physical biology and adjacent disciplines. The volume is structured to provide a broad perspective on current state-of-the-art methods and concepts at the heart of chemical and biological behavior, covering the topics of visualization; theory and computation for complexity; macromolecular function, protein folding, and protein misfolding; molecular recognition; and systems integration from cells to consciousness.The scope of tools is wide-ranging, spanning imaging, crystallography, microfluidics, single-molecule spectroscopy, and synthetic probe targeting, either molecular or by metallic particles. The perspectives are from the point of view of world leaders in physics, chemistry, and biology; and they define potential new frontiers at the interface of these disciplines, including physical, systems, and synthetic biology.

ISBN 1848162006   Pages 450 ISBN13 9781848162006 (What's this?)   Volumes 1 Publisher Imperial College Press   Weight (grammes) 1089 Imprint Imperial College Press   Published in London Format Paperback   Height (mm) 226 Publication date 01 Apr 2008   Width (mm) 155 Library of Congress 2008009371   Spine width (mm) 33 DEWEY 570   Academic level Postgraduate DEWEY edition DC22

		Prologue by Ahmed H. Zewail
Ch. 1		The Preoccupations of Twenty-First-Century Biology by David Baltimore		1
Ch. 2		The World as Physics, Mathematics and Nothing Else by Alexander Varshavsky		7
Ch. 3		Physical Biology: 4D Visualization of Complexity by Ahmed H. Zewail		23
Ch. 4		Revolutionary Developments from Atomic to Extended Structural Imaging by John Meurig Thomas		51
Ch. 5		Physical Biology at the Crossroads by Carlos J. Bustamante		115
Ch. 6		The Challenge of Quasi-Regular Structures in Biology by Roger D. Kornberg		137
Ch. 7		The Future of Biological X-Ray Analysis by Douglas C. Rees		145
Ch. 8		Reinterpreting the Genetic Code: Implications for Macromolecular Design, Evolution and Analysis by David A. Tirrell		165
Ch. 9		Designing Ligands to Bind Tightly to Proteins by George M. Whitesides and Phillip W. Snyder and Demetri T. Moustakas and Katherine A. Mirica		189
Ch. 10		Biology by the Numbers by Rob Phillips		217
Ch. 11		Eppur si muove by Michele Parrinello		247
Ch. 12		Protein Folding and Beyond: Energy Landscapes and the Organization of Living Matter in Time and Space by Peter G. Wolynes		267
Ch. 13		Protein Folding and Misfolding: From Atoms to Organisms by Christopher M. Dobson		289
Ch. 14		A Systems Approach to Medicine Will Transform Healthcare by Leroy Hood		337
Ch. 15		The Neurobiology of Consciousness by Christof Koch and Florian Mormann		367
Ch. 16		Computer-Aided Drug Discovery: Physics-based Simulations from the Molecular to the Cellular Level by J. Andrew McCammon		401
Ch. 17		Precision Measurements in Biology by Stephen R. Quake		411
Ch. 18		Potassium Channels and the Atomic Basis of Selective Ion Conduction by Roderick MacKinnon		431
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Even the shorter contributions, written by masters of their fields, are penetrating. -- Chemistry World "Chemistry World"

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