Process Development

Process development bridges the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. In this concise text the authors use real examples to show the problems which may be encountered in scaling up chemical syntheses and the ways in which these problems may be overcome. The major part of the book is devoted to genuine case histories from ICI/Zeneca Pharmaceuticals. Through a range of carefully chosen examples, the book explains how it is possible to synthesise multi-kilogram quantities of a new organic compound which have been made in the laboratory only on the milligram scale. A wide range of aliphatic, aromatic, and heterocyclic compounds is covered. The book will be of particular value to research chemists who are involved in the development phase of novel compounds and to advanced undergraduate and postgraduate students interested in the fine chemicals industry.

ISBN 0198558244   Volumes 1 ISBN13 9780198558248 (What's this?)   Weight (grammes) 206 Publisher Oxford University Press   Published in Oxford Imprint Oxford University Press   Series editor Davies, Stephen G., Davies, Stephen G., Davies, Stephen G. (Dyson Perrins Laboratory, University of Format Paperback   Series ISSN 30 Publication date 20 Jul 1995   Series title Oxford Chemistry Primers Non-book description v87   Height (mm) 245 Library of Congress RS403.L39   Width (mm) 188 DEWEY 541.39   Spine width (mm) 6 DEWEY edition DC20   Academic level Tertiary education Pages 96

1		Introduction		1
2		Scale-up issues		3
3		Environmental and regulatory issues		12
4		Fun with cephalosporins		15
5		Thromboxane antagonists		27
6		Homochiral thromboxane antagonists		38
7		H[subscript 2] blockers		48
8		Manufacturing route for cloprostenol sodium		57
9		A potential anti-obesity agent		67
10		Reagents for large-scale operation		76
		Index		87

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