"Over the last decades, major progress has been made in quality assurance of hemostatic laboratory assays. This book will be an indispensable part of every hemostasis laboratory, where, given its hands-on nature, it will rarely sit to get dusty on the shelves." -Frits R. Rosendaal, Leiden University Medical Center The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired hemorrhagic and thrombotic disorders. Its role in the monitoring traditional anticoagulant therapy as well as therapy using new anticoagulants presents new challenges to the laboratory. Quality in Laboratory Hemostasis and Thrombosis not only addresses these important issues, but also covers international guidelines for testing, the development of international standard materials, management of hemostasis testing from the laboratory to the point of care as well as molecular genetic testing. Designed as a guide for all those working in hemostasis laboratories, this book details a quality program that, when put into place, will help to improve standards in testing. All of the authors are internationally recognised for their work in hemostasis and thrombosis. Using their experience, they provide information on standards, equipment and methods that will guide the development of a quality program to support all activities in the hemostasis laboratory.
| ISBN | 140516803X | | DEWEY edition | DC22 | | ISBN13 | 9781405168038
(What's this?) | | Pages | 232 | | Publisher | John Wiley and Sons Ltd | | Volumes | 001 | | Imprint | Wiley-Blackwell (an imprint of John Wiley & Sons Ltd) | | Weight (grammes) | 652 | | Format | Hardback | | Published in | Chicester | | Publication date | 19 Dec 2008 | | Height (mm) | 257 | | Writer of foreword | Frits R. Rosendaal | | Width (mm) | 199 | | Library of Congress | RC647 | | Spine width (mm) | 19 | | DEWEY | 616.157075 | | Academic level | Professional / Scholarly |
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Contributors, vii Foreword, x Frits R. Rosendaal Preface, xii 1 General Quality Planning in the Hemostasis Laboratory, 1 John D. Olson 2 Hemostasis Test Validation, Performance and Reference Intervals, 9 Richard A. Marlar 3 International Standards in Hemostasis, 19 Trevor W. Barrowcliffe 4 Sample Integrity and Preanalytical Variables, 31 Dorothy M. Adcock 5 Internal Quality Control in the Hemostasis Laboratory, 43 Steve Kitchen, F. Eric Preston, John D. Olson 6 External Quality Assessment in Hemostasis: Its Importance and Signifi cance, 51 F. Eric Preston, Steve Kitchen, Alok Srivastava 7 Initial Evaluation of Hemostasis: Reagent and Method Selection, 63 Wayne L. Chandler 8 Point-of-Care Testing in Hemostasis, 72 Chris Gardiner, Samuel Machin, Ian Mackie 9 Assay of Factor VIII and Other Clotting Factors, 81 Steve Kitchen, F. Eric Preston 10 Application of Molecular Genetics to the Investigation of Inherited Bleeding Disorders, 90 Stefan Lethagen, Marianne Schwartz, Lars Bo Nielsen 11 Standardization of d-dimer Testing, 99 Guido Reber, Philippe de Moerloose 12 Diagnostic Assessment of Platelet Function, 110 Paquita Nurden, Alan Nurden 13 Laboratory Evaluation of von Willebrand Disease: Phenotypic Analysis, 125 Emmanuel J. Favaloro 14 Laboratory Analysis of von Willebrand Disease: Molecular Analysis, 137 Anne Goodeve, Ian Peake 15 Dilemmas in Heritable Thrombophilia Testing, 147 Isobel D. Walker, Ian Jennings 16 Evaluation of Antiphospholipid Antibodies, 160 Michael Greaves 17 Monitoring Heparin Therapy, 170 Marilyn Johnston 18 Monitoring Oral Anticoagulant Therapy, 179 Armando Tripodi 19 Monitoring New Anticoagulants, 190 Elaine Gray, Trevor W. Barrowcliffe 20 Detecting and Quantifying Functional Inhibitors in Hemostasis, 198 Bert Verbruggen, Irena Novakova, Waander van Heerde Index, 209
"There are particularly useful chapters covering the monitoring of heparin and oral anticoagulation. The book is pretty up to date and even covers the monitoring of new anticoagulants." (The Bulletin of the Royal College of Pathologists, July 2010)
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