Sickle Cell Disease

In 1910, Dr. James B. Herrick published Western medical literature's first description of a person with sickle cell disease. Soon, other physicians reported patients with similar symptoms and confirmed the characteristic feature of the disease: elongated red blood cells. In 1922, the peculiar shape of the cells inspired the official name for the disorder. Within 30 years, scientists had learned about the cause of sickle cell disease - an abnormal form of hemoglobin. "Sickle Cell Disease" explores the scientific discoveries that led to an understanding of the genetic basis of the disease, explaining how a single mutation in hemoglobin multiplies into the many symptoms of sickle cell disease. Also investigated are treatments that help individuals manage sickle cell disease symptoms, and how gene therapy and stem cell therapy may one day lead to a cure for the disease.

ISBN 0791095878   Pages 144 ISBN13 9780791095874 (What's this?)   Volumes 1 Publisher Chelsea House Publishers   Weight (grammes) 454 Imprint Chelsea House Publishers   Published in Broomall Format Hardback   Series title Genes and Disease Publication date 01 Sep 2008   Height (mm) 235 Library of Congress 2008004959   Width (mm) 178 DEWEY 616.1527   Spine width (mm) 13 DEWEY edition DC21   Academic level Secondary education, Tertiary education, Teenage / young adult

1		The Medical Detectives		7
2		Cells: The Body's Protein Factories		19
3		Normal and Mutant Hemoglobins		35
4		How Sickle Cell Hemoglobin Affects Health		49
5		Genetics of Sickle Cell Anemia		60
6		Detecting Sickle Cell Anemia		76
7		Current Treatments for Sickle Cell Anemia		88
8		Potential Treatments for Sickle Cell Anemia		97
9		Sickle Cell Anemia: A History of Ethical Concerns		110
		Glossary		117
		Bibliography		123
		Further Reading		132
		Picture Credits		135
		Index		136
		About the Author		143

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