Susceptibility to Infectious Diseases

In the last fifteen years, substantial progress has been made in identifying why some people are particularly susceptible to specific infectious diseases. Extensive evidence has accumulated that host genes are important determinants of the outcome of infection for many common pathogens. This book summarises advances that have been made in understanding the complexity of host genetic susceptibility. The diseases covered include those of great public health importance such as malaria and HIV, and those of topical interest such as Creutzfeldt-Jakob disease. Many different techniques have been used to identify host genes involved in infectious disease susceptibility. Each chapter describes how these discoveries were made and the book is therefore useful to anyone planning genetic studies on a multi-factorial disease, regardless of whether it has an infectious etiology.

ISBN 0521129591   Pages 424 ISBN13 9780521129596 (What's this?)   Weight (grammes) 620 Publisher Cambridge University Press   Published in Cambridge Imprint Cambridge University Press   Series title Advances in Molecular and Cellular Microbiology Format Paperback   Height (mm) 229 Publication date 04 Feb 2010   Width (mm) 152 DEWEY 616.90442   Spine width (mm) 24 DEWEY edition DC22   Academic level Professional / Scholarly

		Contributors
1		Introduction by Richard Bellamy		1
2		Application of genetic epidemiology to dissecting host susceptibility/resistance to infection illustrated with the study of common mycobacterial infections by Laurent Abel		7
3		The diverse genetic basis of immunodeficiencies by Mauno Vihinen		45
4		Genetic diversity in the major histocompatibility complex and the immune response to infectious diseases by Mark R. Thursz		77
5		The cystic fibrosis transmembrane conductance regulator by Ahn W. Cuthbert		117
6		The influence of inherited traits on malaria infection by Thomas Williams		139
7		Polymorphic chemokine receptor and ligand genes in HIV infection by Richard A. Kaslow		185
8		NRAMP 1 and resistance to intracellular pathogens by Erwin Schurr		221
9		The interleukin-12/interferon-γ loop is required for protective immunity to experimental and natural infections by Mycobacterium by Jean-Laurent Casanova		259
10		Mannose-binding lectin deficiency and susceptibility to infectious disease by Malcolm W. Turner		279
11		Blood group phenotypes and infectious diseases by Anthony Busuttil		309
12		Genetics of human susceptibility to infection and hepatic disease caused by schistosomes by Christophe Chevillard		337
13		Genetic susceptibility to prion diseases by J. W. Ironside		361
		Index		393

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