Textbook of Pulmonary Vascular Disease

"Textbook of Pulmonary Vascular Diseases" combines basic scientific knowledge on the pulmonary circulatory system at levels of the molecule, cell, tissue, and organ with clinical diagnosis and treatment of pulmonary vascular diseases. State-of-the-art techniques and their potential applications in research, diagnosis, and treatment of pulmonary vascular diseases are also covered.

ISBN 0387874283   Pages 1690 ISBN13 9780387874289 (What's this?)   Volumes 1 Publisher Springer-Verlag New York Inc.   Weight (grammes) 4740 Imprint Springer-Verlag New York Inc.   Published in New York, NY Format Hardback   Height (mm) 279 Publication date 01 Jan 2010   Width (mm) 210 DEWEY 616.24   Spine width (mm) 70 DEWEY edition DC22   Academic level Professional / Scholarly

The Human Pulmonary Circulation: Historical Introduction.- Microcirculation of the Lung: Functional and Anatomic Aspects.- Pulmonary Vascular Development.- Pulmonary Vascular Function.- Pulmonary Vascular Mechanics.- Modeling of the Pulmonary Vasculature.- Metabolic and Clearance Function at the Pulmonary Microvascular Endothelial Surface in Pulmonary Hypertension.- The Pharmacology of the Major Vasoactive Mediators Relevant to the Pathogenesis of Pulmonary Hypertension.- The Normal Fetal and Neonatal Pulmonary Circulation.- Excitation-contraction Coupling and Regulation of Pulmonary Vascular Contractility.- Endothelial Regulation of Pulmonary Vascular Tone.- Acute Lung Injury: The Injured Lung Endothelium, Therapeutic Strategies for Barrier Protection and Vascular Biomarkers.- Ion Channels and Transporters in the Pulmonary Vasculature: A Focus on Smooth Muscle.- Receptor-mediated Signal Transduction and Cell Signaling.- Role of Calcium as a Second Messenger in Signaling: A Focus on Endothelium.- Caveolae and Signaling in Pulmonary Vascular Endothelial and Smooth Muscle Cells.- The Chemistry of Biological Gases.- Role of Oxygen-derived Species in the Regulation of Pulmonary Vascular Tone.- Mitochondrial ROS and Redox State in Pulmonary Vascular O2 Sensing.- Cellular and Molecular Mechanisms of Pulmonary Vascular Smooth Muscle Cell Proliferation.- Role of Ca2+ in Vascular Smooth Muscle Gene Expression and Proliferation.- Biochemistry and Cellular Mechanisms of Apoptosis in Vascular Smooth Muscle and Endothelial Cells.- The Coagulation Cascade and its Regulation.- Platelets in Pulmonary Vascular Physiology and Pathology.- Lysis and Organization of Pulmonary Thromboemboli.- Interactions of Leukocytes and Coagulation Factors with the Vessel Wall.- Interaction of the Plasminogen System with the Vessel Wall.- Endothelial Apoptosis and Repair in Pulmonary Arterial Hypertension.- Bronchial Arterial Circulation in the Human.- Animal Models of Pulmonary Hypertension.- Transgenic and Gene Targeted Mouse Models for Pulmonary Hypertension.- Animal Models of Increased Lung Vascular Permeability.- Isolation and Culture of Pulmonary Vascular Smooth Muscle and Endothelial Cells.- Conventional Patch Clamp Techniques and High-throughput Patch Clamp Recordings on a Chip for Measuring Ion Channel Activity.- Measurement of Pulmonary Vascular Structure and Pulmonary Blood Distribution by MDCT and MR Imaging Techniques.- Quantification of DNA, RNA and Protein Expression.- Gene Cloning, Transfection and Mutagenesis.- Approaches for Manipulation of Gene Expression.- Bioinformatics, Genomics, and Functional Genomics: Overview.- Genomic Application to Study Pulmonary Hypertension.- Proteomics and Functional Proteomics.- Maintenance, Propagation and Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells.- Identification of Adult Stem and Progenitor Cells in the Pulmonary Vasculature.- Differentiation of Embryonic Stem Cells to Vascular Cell Lineages.- Statistics and Clinical Data Analysis: A Reference Guide.- Hypoxic Pulmonary Vasoconstriction.- Pathogenic Roles of Ca2+ and Ion Channels in Hypoxia-mediated Pulmonary Hypertension.- Roles of Endothelium-derived Vasoactive and Mitogenic Factors in the Development of Chronic Hypoxia-mediated Pulmonary Hypertension.- Oxygen-sensitive Transcription Factors and Hypoxia-mediated Pulmonary Hypertension.- Developmental Regulation of Pulmonary Vascular Oxygen Sensing.- Pulmonary Vascular Remodeling by High Oxygen.- Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms.- Carbon Monoxide and Heme Oxygenase in the Regulation of Pulmonary Vascular Function and Structure.- Shear Stress, Cell Signaling and Pulmonary Vascular Remodeling.- Pulmonary Hypertension and the Extracellular Matrix.- Role of Progenitor Cells in Pulmonary Vascular Remodeling.- Receptor Signaling in Pulmonary Arterial Hypertension.- Role of Endothelium in the Development of Pulmonary Hypertension.- Coagulation and

From the reviews: "The book begins by detailing the known elements of structure and physiology, then outlines several research tools commonly used in the investigation of pulmonary vasculature before covering mechanisms of pulmonary vascular injury, disease states, and available treatment. ! The intended audience centers on clinicians, but physician scientists, principal investigators, and others with an interest in pulmonary vascular research also can use it as a reference. ! This is a unique book and has no comparison. ! I will refer to this text regularly." (Warren Bradley Fields, Doody's Review Service, August, 2011)

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