The Fetal Matrix: Evolution, Development and Disease

New discoveries reveal how crucial interactions which determine our destiny occur before birth, when our genes interact with their environment as the embryo and fetus develop. These processes - in the matrix of the womb - are evolutionary echoes of mechanisms which allowed our hunter-gatherer ancestors to survive. These exciting insights into predictive adaptive responses suggest new ways of protecting the health of the fetus, infant and adult. If inappropriate they can trigger obesity, diabetes and heart disease, formerly thought to result solely from adult lifestyle. The new concepts in this book are crucial to understanding the daunting public health burden in societies undergoing rapid transition from poverty to affluence. They add an important new dimension to evolutionary theory. Synthesising developmental biology, evolutionary history, medical science, public health and social policy, this is a ground-breaking and fascinating account by two of the world's leading pioneers in this important emerging field.

ISBN 0521834570   Pages 268 ISBN13 9780521834575 (What's this?)   Volumes 1 Publisher Cambridge University Press   Weight (grammes) 700 Imprint Cambridge University Press   Published in Cambridge Format Hardback   Height (mm) 247 Publication date 18 Nov 2004   Width (mm) 174 Library of Congress QH491 .G584 2005   Spine width (mm) 19 DEWEY 612.64   Academic level Tertiary education, Professional / Scholarly DEWEY edition DC22

1		Shaping our destiny : genes, environment and their interactions		1
2		Mother and fetus		25
3		Fetal choices		59
4		Predictive adaptive responses and human disease		78
5		Obesity, diabetes and other diseases		103
6		The biology of predictive adaptive responses		118
7		Predictive adaptive responses - critical processes in evolution		144
8		Evolutionary echoes and the human camel		173
9		Improving human health		190
10		Fetal futures		206

'Gluckman and Hanson argue that the interaction between mammals and their environment while in the womb irreversibly affects their future development, what they call a 'predictive adaptive response'. It also has huge health implications for the rest of their lives. The authors are persuasive, and their findings have relevance for health policy everywhere. If maternal well-being affects the lifelong health of the offspring, it makes good sense to ensure that mothers are always well cared for.' New Scientist 'In an ideal world The Fetal Matrix would be taken more seriously than any other book on health and nutrition purlished in the past year.' FT Magazine 'Those seeking an alternative to the current preventive approaches focused on healthy choices by adults should certainly read Gluckman and Hanson's book. The book itself provides a clear description of the origin and development of a provocative and truly original idea.' Journal of the Royal Society of Medicine 'The Fetal Matrix by Peter Gluckman and Mark Hanson is a fascinating and important book about the responses of the mammalian fetus to its environment ... a thought-provoking account of a topic in which developmental biology, physiology and clinical medicine intersect.' Nature 'The biological interpretation of disease and health is a topic in need of serious attention and wider dissemination. In The Fetal Matrix, Gluckman and Hanson have made a very interesting contribution to this enterprise. ... they have introduced, in a very readable fashion, an idea that is likely to receive further attention.' Biologist

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