Thrombolytic Therapy for Acute Stroke

This extensively revised and expanded second edition incorporates the knowledge gained from the widespread implementation of large rt-PA for acute stroke trials and demonstrates the power of the new technologies now available. The authors have included much new material on stroke-MRI and computed omogaraphy, and updated all chapters describing the background, use, and nuances of thrombolytic therapy. They present everything one needs to know for proper patient selection, the key to successful treatment. Practical how-to chapters guide the reader in treating acute stroke patients, both with and without thrombolytic therapy. New detailed practice cases that simulate making the rounds in a world-class stroke center prepare practitioners to be as ready as possible for their first case.

ISBN 158829398X   Pages 392 ISBN13 9781588293985 (What's this?)   Volumes 1 Publisher Humana Press Inc.   Weight (grammes) 826 Imprint Humana Press Inc.   Published in Totowa, NJ Format Hardback   Series title Current Clinical Neurology Publication date 24 Mar 2005   Height (mm) 229 Library of Congress 2005000628   Width (mm) 152 DEWEY 616.810651   Spine width (mm) 26 DEWEY edition DC22   Academic level Professional / Scholarly

1		Mechanisms of thrombolysis by Gregory J. del Zoppo and Naohisa Hosomi		3
2		Pathology of cervico-cranial artery occlusion by Louis R. Caplan		29
3		The ischemic penumbra and neuronal salvage by Patrick D. Lyden		43
4		Pre-clinical testing of thrombolytic therapy for acute ischemic stroke by Steven R. Levine		65
5		Combination of thrombolytic therapy with neuroprotectants by James C. Grotta and Lise A. Labiche		77
6		Pilot and preliminary studies of thrombolytic therapy for stroke by Steven R. Levine and E. Clarke Haley and Patrick D. Lyden		95
7		Intravenous thrombolytic therapy for acute ischemic stroke : results of large randomized clinical trials by Matthew L. Flaherty and Edward C. Jauch and Rashmi U. Kothari and Joseph P. Broderick		111
8		Further analysis of NINDS study : long-term outcome, subgroups, and cost effectiveness by Susan C. Fagan and Thomas D. Kwiatkowski and Patrick D. Lyden		129
9		Community experience with intravenous thrombolysis for acute stroke by Lama Al-Khoury and Christy M. Jackson		149
10		Intra-arterial thrombolysis in acute ischemic stroke by Anthony J. Furlan and Randall Higashida and Irene Katzan and Alex Abou-Chebl and Andrew N. Russman		159
11		Combinations of intravenous and intra-arterial thrombolysis by Matthew L. Flaherty and Joseph Broderick		185
12		Thrombolysis in vertebrobasilar occulsive disease by Louis R. Caplan		203
13		Thrombolytic therapy in stroke patients by Patrick D. Lyden		211
14		Stroke thrombolysis : the present guidelines and policies for clinical use should be changed by Louis R. Caplan		223
15		How to run a stroke code by Askiel Bruno		235
16		The impact of computed tomography on acute stroke treatment by Rudiger von Kummer		249
17		Using magnetic resonance imaging to select and manage patients for treatment by Peter D. Schellinger and Chelsea S. Kidwell and Steven Warach		279
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Reviews of the first edition: "...the authors succeeded very well in their intention to make a reference work that is based not only on scientific evidence but also on their own experience in the field." - Acta Neurologica Belgica "This is very much a hands on book, with much practical advice, ranging from detailed advice about the assessment and selection of patients for thrombolysis to how to set up and deliver an emergency service for stroke. The book ranges from a detailed description of the evidence from clinical trials to advice based on personal experience...proceeds to an excellent account of the early trials of thrombolysis...an excellent chapter follows on the techniques and interpretation of CT in acute stroke...the book is highly recommended as a guide to current practice for those contemplating introducing thrombolysis into their clinical practice." - Journal of Neurology, Neurosurgery, and Psychiatry "The purpose is to bring all individuals who actively manage stroke up-to-date with the current literature. The author adequately accomplishes this by doing a comprehensive review of the available research published in this field. The objectives are quite worthy and well met...The author has taken care of stroke patients for years and thus is a credible authority on the subject. The book covers all aspects of the clinical trials, outcomes, and current arguments in the field of thrombolysis. There is an excellent chapter that offers opinions from several stroke experts. Finally, the case presentations at the end of the book are well done and helpful. This is a nice wrap-up of the material. This is an excellent overview of current literature on thrombolysis for stroke. I would highly recommend it for anyone who manages the acute stroke patient. It is probably one of the best I have seen on the topic."-Doody's Health Sciences Book Review Journal "The authors of this fine reference book cover all aspects of thrombolytic therapy related to cerebral ischaemia. From the pathophysiology to analysis of scientific studies to clinical use, the information in these 18 chapters may be useful to any of the physicians who threat patients in the first few hours after stroke: neurologists, neurosurgeons, emergency medicine physicians, internists, and radiologists...The authors provide data necessary for understanding the indications and limitations of thrombolytic therapy, so that even the practitioners unfamiliar with the subject can obtain sufficient information for evaluation of potential patients...All chapters are well referenced with up-to-date citations. In summary, the editor, Patrick D. Layden, has orchestrated the assembly of a superb book that provides a comprehensive source of information on thrombolytic therapy for acute stroke patients." - European Journal of Emergency Medicine "Co-authored by many leaders in the field of acute stroke therapy, this book represents a thorough yet concise primer on stroke thrombolysis...The strength of this book lies in its balance: it provides the reader with enough of a knowledge base to develop a good understanding of the issues surrounding stroke thrombolysis, whereas avoiding information overload. The writing is generally clear, concise, and well referenced...The chapters are accompanied with informative tables and well reproduced imaging studies. The case presentations at the end provide an excellent opportunity for the reader to take what has been learned and apply it to real patient scenarios...This book is intended for the wide range of clinicians involved in the care of acute stroke patients, including neurology residents, neurologists, neurosurgeons, emergency physicians, primary care providers, and emergency service coordinators."- Neurology, Official Journal of the American Academy of Neurology

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