Understanding Immunology

Understanding Immunology is a well-established introduction to this complex subject for readers with no previous exposure. It is aimed primarily at undergraduates in biological sciences, biomedical sciences and medicine. The selection and order of topic coverage is designed to instruct effectively, and a variety of boxed examples add depth and historical context for those readers wanting to go beyond the essentials. The first part of the book (Chapters 1 to 11) takes students through the pathogenesis of infectious diseases and describes the molecules, cells and tissues of the immune system that provide protection against a wide variety of pathogens. It also describes how mankind has utilised the immune system, from the development of vaccines to the production of reagents for use in the clinic and laboratory. The final four chapters describe how the immune system operates in disease situations such as allergy, autoimmunity and transplantation. This third edition is revised to cover the latest experimental and clinical changes in the subject, particularly those in the development of lymphocytes; the different types of CD4 helper T cells; the use of antibodies, including monoclonal antibodies, as experimental and clinical tools; and immunological tolerance. Dr. Peter Wood is a Lecturer in the Faculty of Life Sciences at the University of Manchester. He has over 20 years of teaching experience, both in the UK and in the USA, and is widely published in the literature. His current research interest is the role of cytokines in the development of diabetes.

ISBN 0273730681   Pages 392 ISBN13 9780273730682 (What's this?)   Weight (grammes) 592 Publisher Pearson Education Limited   Published in Harlow Imprint Prentice-Hall   Series title Cell and Molecular Biology in Action Format Paperback   Previous ISBN 9780131968455 Publication date 31 Mar 2011   Height (mm) 234 DEWEY 616.079   Width (mm) 156 DEWEY edition DC22   Academic level Undergraduate

Contents Preface Acknowledgements 1 The threat to the body: the role and requirements of the immune system 1.1 The role and complexity of the immune system 1.2 Pathogens differ in size, lifestyle and how they cause disease 1.3 How do pathogens cause disease and what protection is there? 1.4 Conclusion 1.5 Summary 1.6 Questions and answers 1.7 Further reading 2 The immediate response to infection: innate immunity and the inflammatory response 2.1 The response to infection 2.2 The immediate response to infection the innate immune system 2.3 Cytokines hormones of the immune system 2.4 The inflammatory response and cell migration 2.5 Cell migration through blood and into tissue 2.6 The inflammatory response 2.7 Systematic inflammation involvement of the brain and liver 2.8 Opsonins cans 2.9 Interferons and natural killer cells 2.10 The innate immune response limits the early replication of pathogens 2.11 Summary 2.12 Questions and answers 2.13 Further reading 3 Specific immune recognition: B lymphocytes and the antibody molecule 3.1 Introduction to the specific immune system 3.2 Antibody structure 3.3 Recognition by antibody antigens and epitopes 3.4 There are different antibody classes with different biological functions 3.5 Antibody can be secreted or expressed on the cell surface of B lymphocytes 3.6 Summary 3.7 Questions and answers 3.8 Further reading 4 T lymphocytes and MHC-associated recognition of antigen 4.1 There are different types of T lymphocytes 4.2 T cells recognise antigen through their T cell receptor (TCR) 4.3 The major histocompatibility complex 4.4 Recognition of antigen by T cells 4.5 Antigens must be processed before they can be presented by MHC molecules 4.6 Summary; 4.7 Questions and answers 4.8 Further reading 5 Lymphocyte development and the generation of antigen receptors 5.1 The production of lymphocytes: lymphopoiesis 5.2 B lymphocytes are produced in the bone marrow 5.3 T lymphocytes finish their production in the thymus 5.4 During their development lymphocytes must generate huge numbers of Ig and TCR receptors with different antigen specificities 5.5 Developing lymphocytes rearrange their lg or TCR genes in a carefully controlled order 5.6 Why is there continuous production of lymphocytes, most of which die? 5.7 Summary 5.8 Questions and answers 5.9 Further reading 6 Anatomy of the immune system 6.1 Requirements of the immune system in vivo 6.2 Different pathogens require different types of immune responses 6.3 The anatomy of the lymphoid system promotes the interaction of cells and antigen 6.4 Lymphocytes continually recirculate through blood, tissues and lymphatic vessels 6.5 Summary 6.6 Questions and answers 6.7 Further reading 7 Anatomical and cellular aspects of antibody production 7.1 Overview of antibody production 7.2 Activation of CD4 T cells (0 5 days) & 7.3 Stimulation of B cells by antigen and their interaction with Th (0 5 days after antigen) 7.4 Formation of germinal centres (4 14 days after antigen) 7.5 MALT and the production of IgA 7.6 Summary 7.7 Questions and answers 7.8 Further reading 8 Effector mechanisms: dealing with pathogens in vivo (1) Antibody-mediated responses 8.1 Humoral and cell-mediated immunity 8.2 Antibodies provide protection in many different ways 8.3 Neutralisation by antibody 8.4 Antibodies can cause agglutination of microbes 8.5 Antibodies can act as opsonins and promote phagocytosis 8.6 Complement is a protein cascade with antimicrobial functions 8.7 Antibody and complement synergise to promote the opsonisation of microbes 8.8 Antibody-dependent cell-mediated cytoxicity (ADCC) 8.9 Summary 8.10 Questions and answers 8.11 Further reading 9 Effector mechanisms: dealing with pathogens in vivo (2) Cell-mediated immunity 9.1 Introduction 9.2 CD4 T cells develop into different types of helper T cells 9.3 CD8 cytotox

"Nice book size, clear helpful diagrams and reasonable sized chapters, useful glossary. Helpful revision and updates in a fast changing field" - Peter Bentley, Head of Biology Department, City University "A very accessible text for students. The diagrams are clear and there are good Q&A sections" - Anne Humphreys, Senior Lecturer in Microbiology, Faculty of Science, Liverpool John Moores University

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